Cargando…

Interfering with nucleotide excision by the coronavirus 3′-to-5′ exoribonuclease

Mostrar otras versiones (1)

Some of the most efficacious antiviral therapeutics are ribonucleos(t)ide analogs. The presence of a 3′-to-5′ proofreading exoribonuclease (ExoN) in coronaviruses diminishes the potency of many ribonucleotide analogs. The ability to interfere with ExoN activity will create new possibilities for cont...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chinthapatla, Rukesh, Sotoudegan, Mohamad, Srivastava, Pankaj, Anderson, Thomas K, Moustafa, Ibrahim M, Passow, Kellan T, Kennelly, Samantha A, Moorthy, Ramkumar, Dulin, David, Feng, Joy Y, Harki, Daniel A, Kirchdoerfer, Robert N, Cameron, Craig E, Arnold, Jamie J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841423/ https://www.ncbi.nlm.nih.gov/pubmed/36546762 http://dx.doi.org/10.1093/nar/gkac1177

Ejemplares similares

Interfering with nucleotide excision by the coronavirus 3’-to-5’ exoribonuclease
por: Chinthapatla, Rukesh, et al.
Publicado: (2022)

Structural basis for the evolution of cyclic phosphodiesterase activity in the U6 snRNA exoribonuclease Usb1
por: Nomura, Yuichiro, et al.
Publicado: (2020)

Collaborator of alternative reading frame protein (CARF) regulates early processing of pre-ribosomal RNA by retaining XRN2 (5′-3′ exoribonuclease) in the nucleoplasm
por: Sato, Shigeko, et al.
Publicado: (2015)

HELZ2: a new, interferon-regulated, human 3′-5′ exoribonuclease of the RNB family is expressed from a non-canonical initiation codon
por: Huntzinger, Eric, et al.
Publicado: (2023)

Processing of the Escherichia coli leuX tRNA transcript, encoding tRNA(Leu5), requires either the 3′→5′ exoribonuclease polynucleotide phosphorylase or RNase P to remove the Rho-independent transcription terminator
por: Mohanty, Bijoy K., et al.
Publicado: (2010)

The helicase XPD unwinds bubble structures and is not stalled by DNA lesions removed by the nucleotide excision repair pathway
por: Rudolf, Jana, et al.
Publicado: (2010)

The ATPase mechanism of UvrA(2) reveals the distinct roles of proximal and distal ATPase sites in nucleotide excision repair
por: Case, Brandon C, et al.
Publicado: (2019)

Complementation of aprataxin deficiency by base excision repair enzymes
por: Çağlayan, Melike, et al.
Publicado: (2015)

Domain swapping between FEN-1 and XPG defines regions in XPG that mediate nucleotide excision repair activity and substrate specificity
por: Hohl, Marcel, et al.
Publicado: (2007)

USER™ friendly DNA engineering and cloning method by uracil excision
por: Bitinaite, Jurate, et al.
Publicado: (2007)

Human DNA polymerase θ possesses 5′-dRP lyase activity and functions in single-nucleotide base excision repair in vitro
por: Prasad, Rajendra, et al.
Publicado: (2009)

The wobble nucleotide-excising anticodon nuclease RloC is governed by the zinc-hook and DNA-dependent ATPase of its Rad50-like region
por: Klaiman, Daniel, et al.
Publicado: (2012)

Participation of RecJ in the base excision repair pathway of Deinococcus radiodurans
por: Cheng, Kaiying, et al.
Publicado: (2020)

In vitro selection of DNA-cleaving deoxyribozyme with site-specific thymidine excision activity
por: Wang, Mingqi, et al.
Publicado: (2014)

Pol β associated complex and base excision repair factors in mouse fibroblasts
por: Prasad, Rajendra, et al.
Publicado: (2012)

A discontinuous DNA glycosylase domain in a family of enzymes that excise 5-methylcytosine
por: Ponferrada-Marín, María Isabel, et al.
Publicado: (2011)

Restriction-modification system with methyl-inhibited base excision and abasic-site cleavage activities
por: Fukuyo, Masaki, et al.
Publicado: (2015)

Immunodetection of human topoisomerase I-DNA covalent complexes
por: Patel, Anand G., et al.
Publicado: (2016)

AZT resistance of simian foamy virus reverse transcriptase is based on the excision of AZTMP in the presence of ATP
por: Hartl, Maximilian J., et al.
Publicado: (2008)

Rev1 is a base excision repair enzyme with 5′-deoxyribose phosphate lyase activity
por: Prasad, Rajendra, et al.
Publicado: (2016)

Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair
por: Li, Ya-Qiang, et al.
Publicado: (2007)

Identification of a residue critical for the excision of 3′-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family
por: Castillo-Acosta, Víctor M., et al.
Publicado: (2009)

Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidases
por: Woods, Ryan D., et al.
Publicado: (2016)

Backtracking behavior in viral RNA-dependent RNA polymerase provides the basis for a second initiation site
por: Dulin, David, et al.
Publicado: (2015)

Structural basis for recognition and repair of the 3′-phosphate by NExo, a base excision DNA repair nuclease from Neisseria meningitidis
por: Silhan, Jan, et al.
Publicado: (2018)

Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates
por: Wong, Heng-Kuan, et al.
Publicado: (2007)

Specialization of an Exonuclease III family enzyme in the repair of 3′ DNA lesions during base excision repair in the human pathogen Neisseria meningitidis
por: Silhan, Jan, et al.
Publicado: (2012)

Temperature controlled high-throughput magnetic tweezers show striking difference in activation energies of replicating viral RNA-dependent RNA polymerases
por: Seifert, Mona, et al.
Publicado: (2020)

Excision-reintegration at a pneumococcal phase-variable restriction-modification locus drives within- and between-strain epigenetic differentiation and inhibits gene acquisition
por: Kwun, Min Jung, et al.
Publicado: (2018)

Human DNA polymerase β polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity
por: Guo, Zhigang, et al.
Publicado: (2009)

Identification of a conserved 5′-dRP lyase activity in bacterial DNA repair ligase D and its potential role in base excision repair
por: de Ory, Ana, et al.
Publicado: (2016)

Structural and kinetic insights into binding and incorporation of L-nucleotide analogs by a Y-family DNA polymerase
por: Gaur, Vineet, et al.
Publicado: (2014)

Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors
por: Schneider, Anna, et al.
Publicado: (2016)

SARS-CoV-2 nsp14 Exoribonuclease Removes the Natural Antiviral 3′-Deoxy-3′,4′-didehydro-cytidine Nucleotide from RNA
por: Moeller, Nicholas H., et al.
Publicado: (2022)

Quantitative parameters of bacterial RNA polymerase open-complex formation, stabilization and disruption on a consensus promoter
por: Bera, Subhas C, et al.
Publicado: (2022)

The checkpoint clamp, Rad9-Rad1-Hus1 complex, preferentially stimulates the activity of apurinic/apyrimidinic endonuclease 1 and DNA polymerase β in long patch base excision repair
por: Gembka, Agnieszka, et al.
Publicado: (2007)

Time-resolved fluorescence studies of nucleotide flipping by restriction enzymes
por: Neely, Robert K., et al.
Publicado: (2009)

Critical role of DNA intercalation in enzyme-catalyzed nucleotide flipping
por: Hendershot, Jenna M., et al.
Publicado: (2014)

PCNA accelerates the nucleotide incorporation rate by DNA polymerase δ
por: Mondol, Tanumoy, et al.
Publicado: (2019)

Mammalian Nudix proteins cleave nucleotide metabolite caps on RNAs
por: Sharma, Sunny, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_98bk13dt637b5funjd330amqsc