SigH stress response mediates killing of Mycobacterium tuberculosis by activating nitronaphthofuran prodrugs via induction of Mrx2 expression

The emergence of drug-resistant Mycobacterium tuberculosis strains highlights the need to discover anti-tuberculosis drugs with novel mechanisms of action. Here we discovered a mycobactericidal strategy based on the prodrug activation of selected chemical derivatives classified as nitronaphthofurans...

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Detalles Bibliográficos
Autores principales: Cioetto-Mazzabò, Laura, Boldrin, Francesca, Beauvineau, Claire, Speth, Martin, Marina, Alberto, Namouchi, Amine, Segafreddo, Greta, Cimino, Mena, Favre-Rochex, Sandrine, Balasingham, Seetha, Trastoy, Beatriz, Munier-Lehmann, Hélène, Griffiths, Gareth, Gicquel, Brigitte, Guerin, Marcelo E, Manganelli, Riccardo, Alonso-Rodríguez, Noelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841431/
https://www.ncbi.nlm.nih.gov/pubmed/36546765
http://dx.doi.org/10.1093/nar/gkac1173

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