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Structural basis of DNA polymerase θ mediated DNA end joining

DNA polymerase θ (Pol θ) plays an essential role in the microhomology-mediated end joining (MMEJ) pathway for repairing DNA double-strand breaks. However, the mechanisms by which Pol θ recognizes microhomologous DNA ends and performs low-fidelity DNA synthesis remain unclear. Here, we present cryo-e...

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Detalles Bibliográficos
Autores principales:	Li, Chuxuan, Zhu, Hanwen, Jin, Shikai, Maksoud, Leora M, Jain, Nikhil, Sun, Ji, Gao, Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841435/ https://www.ncbi.nlm.nih.gov/pubmed/36583344 http://dx.doi.org/10.1093/nar/gkac1201

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