Subnanomolar Affinity and Selective Antagonism at α7 Nicotinic Receptor by Combined Modifications of 2-Triethylammonium Ethyl Ether of 4-Stilbenol (MG624)

[Image: see text] Modifications of the cationic head and the ethylene linker of 2-(triethylammonium)ethyl ether of 4-stilbenol (MG624) have been proved to produce selective α9*-nAChR antagonism devoid of any effect on the α7-subtype. Here, single structural changes at the styryl portion of MG624 lea...

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Detalles Bibliográficos
Autores principales: Bavo, Francesco, Pallavicini, Marco, Pucci, Susanna, Appiani, Rebecca, Giraudo, Alessandro, Oh, Hyoungil, Kneisley, Dana L., Eaton, Brek, Lucero, Linda, Gotti, Cecilia, Clementi, Francesco, Whiteaker, Paul, Bolchi, Cristiano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841521/
https://www.ncbi.nlm.nih.gov/pubmed/36526469
http://dx.doi.org/10.1021/acs.jmedchem.2c01256

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