Chemical Blockage of the Mitochondrial Rhomboid Protease PARL by Novel Ketoamide Inhibitors Reveals Its Role in PINK1/Parkin-Dependent Mitophagy

[Image: see text] The mitochondrial rhomboid protease PARL regulates mitophagy by balancing intramembrane proteolysis of PINK1 and PGAM5. It has been implicated in the pathogenesis of Parkinson’s disease, but its investigation as a possible therapeutic target is challenging in this context because g...

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Detalles Bibliográficos
Autores principales: Poláchová, Edita, Bach, Kathrin, Heuten, Elena, Stanchev, Stancho, Tichá, Anežka, Lampe, Philipp, Majer, Pavel, Langer, Thomas, Lemberg, Marius K., Stříšovský, Kvido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841525/
https://www.ncbi.nlm.nih.gov/pubmed/36540942
http://dx.doi.org/10.1021/acs.jmedchem.2c01092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841525/
https://www.ncbi.nlm.nih.gov/pubmed/36540942
http://dx.doi.org/10.1021/acs.jmedchem.2c01092

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