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Microtubule-Stabilizing 1,2,4-Triazolo[1,5-a]pyrimidines as Candidate Therapeutics for Neurodegenerative Disease: Matched Molecular Pair Analyses and Computational Studies Reveal New Structure–Activity Insights

[Image: see text] Microtubule (MT)-stabilizing 1,2,4-triazolo[1,5-a]pyrimidines (TPDs) hold promise as candidate therapeutics for Alzheimer’s disease (AD) and other neurodegenerative conditions. However, depending on the choice of substituents around the TPD core, these compounds can elicit markedly...

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Detalles Bibliográficos
Autores principales:	Alle, Thibault, Varricchio, Carmine, Yao, Yuemang, Lucero, Bobby, Nzou, Goodwell, Demuro, Stefania, Muench, Megan, Vuong, Khoa D., Oukoloff, Killian, Cornec, Anne-Sophie, Francisco, Karol R., Caffrey, Conor R., Lee, Virginia M.-Y., Smith, Amos B., Brancale, Andrea, Brunden, Kurt R., Ballatore, Carlo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841533/ https://www.ncbi.nlm.nih.gov/pubmed/36534051 http://dx.doi.org/10.1021/acs.jmedchem.2c01411

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