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Unusual magnetic resonance imaging findings of cystic bone lesions in congenital generalized lipodystrophy
Cystic bone lesions are the hallmark of skeletal abnormalities in patients with congenital generalized lipodystrophy (CGL). However, their pathophysiology is still unclear and theories about their origin remain largely speculative. This article reports on a patient with CGL and cystic bone lesions,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841538/ https://www.ncbi.nlm.nih.gov/pubmed/36348607 http://dx.doi.org/10.4103/jpgm.jpgm_1031_21 |
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author | de Oliveira, TFT Natal, MRC Teixeira, AA Machado, BB |
author_facet | de Oliveira, TFT Natal, MRC Teixeira, AA Machado, BB |
author_sort | de Oliveira, TFT |
collection | PubMed |
description | Cystic bone lesions are the hallmark of skeletal abnormalities in patients with congenital generalized lipodystrophy (CGL). However, their pathophysiology is still unclear and theories about their origin remain largely speculative. This article reports on a patient with CGL and cystic bone lesions, some of them with unusual magnetic resonance imaging (MRI) findings that include elevated signal intensity on T1-weighted images and fluid–fluid levels, the latter evolving to a more “classic” cystic appearance on follow-up. Even though similar findings were first described almost 30 years ago, little attention was given to them back then; furthermore, other than the present report, no other study has performed sequential exams to follow their evolution in serial MRI. The authors conduct a review of the literature, hypothesizing that these remarkable findings may reflect an intermediate stage in the process of cystification of the abnormal bone marrow, incapable to perform adipose conversion, lending factual support to the modern theories about this issue. |
format | Online Article Text |
id | pubmed-9841538 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-98415382023-01-17 Unusual magnetic resonance imaging findings of cystic bone lesions in congenital generalized lipodystrophy de Oliveira, TFT Natal, MRC Teixeira, AA Machado, BB J Postgrad Med Case Report Cystic bone lesions are the hallmark of skeletal abnormalities in patients with congenital generalized lipodystrophy (CGL). However, their pathophysiology is still unclear and theories about their origin remain largely speculative. This article reports on a patient with CGL and cystic bone lesions, some of them with unusual magnetic resonance imaging (MRI) findings that include elevated signal intensity on T1-weighted images and fluid–fluid levels, the latter evolving to a more “classic” cystic appearance on follow-up. Even though similar findings were first described almost 30 years ago, little attention was given to them back then; furthermore, other than the present report, no other study has performed sequential exams to follow their evolution in serial MRI. The authors conduct a review of the literature, hypothesizing that these remarkable findings may reflect an intermediate stage in the process of cystification of the abnormal bone marrow, incapable to perform adipose conversion, lending factual support to the modern theories about this issue. Wolters Kluwer - Medknow 2022 2022-11-04 /pmc/articles/PMC9841538/ /pubmed/36348607 http://dx.doi.org/10.4103/jpgm.jpgm_1031_21 Text en Copyright: © 2022 Journal of Postgraduate Medicine https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Case Report de Oliveira, TFT Natal, MRC Teixeira, AA Machado, BB Unusual magnetic resonance imaging findings of cystic bone lesions in congenital generalized lipodystrophy |
title | Unusual magnetic resonance imaging findings of cystic bone lesions in congenital generalized lipodystrophy |
title_full | Unusual magnetic resonance imaging findings of cystic bone lesions in congenital generalized lipodystrophy |
title_fullStr | Unusual magnetic resonance imaging findings of cystic bone lesions in congenital generalized lipodystrophy |
title_full_unstemmed | Unusual magnetic resonance imaging findings of cystic bone lesions in congenital generalized lipodystrophy |
title_short | Unusual magnetic resonance imaging findings of cystic bone lesions in congenital generalized lipodystrophy |
title_sort | unusual magnetic resonance imaging findings of cystic bone lesions in congenital generalized lipodystrophy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841538/ https://www.ncbi.nlm.nih.gov/pubmed/36348607 http://dx.doi.org/10.4103/jpgm.jpgm_1031_21 |
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