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Quantum Tunnelling Effects in the Guanine-Thymine Wobble Misincorporation via Tautomerism
[Image: see text] The misincorporation of a noncomplementary DNA base in the polymerase active site is a critical source of replication errors that can lead to genetic mutations. In this work, we model the mechanism of wobble mispairing and the subsequent rate of misincorporation errors by coupling...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841559/ https://www.ncbi.nlm.nih.gov/pubmed/36562711 http://dx.doi.org/10.1021/acs.jpclett.2c03171 |