Characterisation of C101248: A novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome

Neuroinflammation, specifically the NLRP3 inflammasome cascade, is a common underlying pathological feature of many neurodegenerative diseases. Evidence suggests that NLRP3 activation involves changes in intracellular K(+). Nuclear Enriched Transcript Sort Sequencing (NETSseq), which allows for deep...

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Detalles Bibliográficos
Autores principales: Ossola, Bernardino, Rifat, Ali, Rowland, Anna, Hunter, Helen, Drinkall, Samuel, Bender, Clare, Hamlischer, Mayida, Teall, Martin, Burley, Russell, Barker, Daneil F., Cadwalladr, David, Dickson, Louise, Lawrence, Jason M.K., Harvey, Jenna R.M., Lizio, Marina, Xu, Xiao, Kavanagh, Edel, Cheung, Toni, Sheardown, Steve, Lawrence, Catherine B., Harte, Michael, Brough, David, Madry, Christian, Matthews, Kim, Doyle, Kevin, Page, Keith, Powell, Justin, Brice, Nicola L., Bürli, Roland W., Carlton, Mark B., Dawson, Lee A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841576/
https://www.ncbi.nlm.nih.gov/pubmed/36375694
http://dx.doi.org/10.1016/j.neuropharm.2022.109330

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