Iron-Catalyzed Cross-Coupling of α-Allenyl Esters with Grignard Reagents for the Synthesis of 1,3-Dienes

[Image: see text] Structurally diverse 1,3-dienes are valuable building blocks in organic synthesis. Herein we report the iron-catalyzed coupling between α-allenyl esters and Grignard reagents, which provides a fast and practical approach to a variety of complex substituted 1,3-dienes. The reaction...

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Autores principales: Kong, Wei-Jun, Kessler, Simon N., Wu, Haibo, Bäckvall, Jan-E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841610/
https://www.ncbi.nlm.nih.gov/pubmed/36599130
http://dx.doi.org/10.1021/acs.orglett.2c03916
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author Kong, Wei-Jun
Kessler, Simon N.
Wu, Haibo
Bäckvall, Jan-E.
author_facet Kong, Wei-Jun
Kessler, Simon N.
Wu, Haibo
Bäckvall, Jan-E.
author_sort Kong, Wei-Jun
collection PubMed
description [Image: see text] Structurally diverse 1,3-dienes are valuable building blocks in organic synthesis. Herein we report the iron-catalyzed coupling between α-allenyl esters and Grignard reagents, which provides a fast and practical approach to a variety of complex substituted 1,3-dienes. The reaction involves an inexpensive iron catalyst, mild reaction conditions, and provides easy scale up.
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spelling pubmed-98416102023-01-17 Iron-Catalyzed Cross-Coupling of α-Allenyl Esters with Grignard Reagents for the Synthesis of 1,3-Dienes Kong, Wei-Jun Kessler, Simon N. Wu, Haibo Bäckvall, Jan-E. Org Lett [Image: see text] Structurally diverse 1,3-dienes are valuable building blocks in organic synthesis. Herein we report the iron-catalyzed coupling between α-allenyl esters and Grignard reagents, which provides a fast and practical approach to a variety of complex substituted 1,3-dienes. The reaction involves an inexpensive iron catalyst, mild reaction conditions, and provides easy scale up. American Chemical Society 2023-01-04 /pmc/articles/PMC9841610/ /pubmed/36599130 http://dx.doi.org/10.1021/acs.orglett.2c03916 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Kong, Wei-Jun
Kessler, Simon N.
Wu, Haibo
Bäckvall, Jan-E.
Iron-Catalyzed Cross-Coupling of α-Allenyl Esters with Grignard Reagents for the Synthesis of 1,3-Dienes
title Iron-Catalyzed Cross-Coupling of α-Allenyl Esters with Grignard Reagents for the Synthesis of 1,3-Dienes
title_full Iron-Catalyzed Cross-Coupling of α-Allenyl Esters with Grignard Reagents for the Synthesis of 1,3-Dienes
title_fullStr Iron-Catalyzed Cross-Coupling of α-Allenyl Esters with Grignard Reagents for the Synthesis of 1,3-Dienes
title_full_unstemmed Iron-Catalyzed Cross-Coupling of α-Allenyl Esters with Grignard Reagents for the Synthesis of 1,3-Dienes
title_short Iron-Catalyzed Cross-Coupling of α-Allenyl Esters with Grignard Reagents for the Synthesis of 1,3-Dienes
title_sort iron-catalyzed cross-coupling of α-allenyl esters with grignard reagents for the synthesis of 1,3-dienes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841610/
https://www.ncbi.nlm.nih.gov/pubmed/36599130
http://dx.doi.org/10.1021/acs.orglett.2c03916
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