Cargando…
Dopamine Receptor Supports the Potentiation of Intrinsic Excitability and Synaptic LTD in Temporoammonic-CA1 Synapse
Dopaminergic projection to the hippocampus from the ventral tegmental area or locus ceruleus has been considered to play an essential role in the acquisition of novel information. Hence, the dopaminergic modulation of synaptic plasticity in the hippocampus has been widely studied. We examined how th...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society for Brain and Neural Sciences
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841748/ https://www.ncbi.nlm.nih.gov/pubmed/36631845 http://dx.doi.org/10.5607/en22028 |
_version_ | 1784869964764676096 |
---|---|
author | Kim, Hye-Hyun Lee, Suk-Ho Ho, Won-Kyung Eom, Kisang |
author_facet | Kim, Hye-Hyun Lee, Suk-Ho Ho, Won-Kyung Eom, Kisang |
author_sort | Kim, Hye-Hyun |
collection | PubMed |
description | Dopaminergic projection to the hippocampus from the ventral tegmental area or locus ceruleus has been considered to play an essential role in the acquisition of novel information. Hence, the dopaminergic modulation of synaptic plasticity in the hippocampus has been widely studied. We examined how the D1 and D2 receptors influenced the mGluR5-mediated synaptic plasticity of the temporoammonic-CA1 synapses and showed that the dopaminergic modulation of the temporoammonic-CA1 synapses was expressed in various ways. Our findings suggest that the dopaminergic system in the hippocampal CA1 region regulates the long-term synaptic plasticity and processing of the novel information. |
format | Online Article Text |
id | pubmed-9841748 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Korean Society for Brain and Neural Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-98417482023-01-25 Dopamine Receptor Supports the Potentiation of Intrinsic Excitability and Synaptic LTD in Temporoammonic-CA1 Synapse Kim, Hye-Hyun Lee, Suk-Ho Ho, Won-Kyung Eom, Kisang Exp Neurobiol Original Article Dopaminergic projection to the hippocampus from the ventral tegmental area or locus ceruleus has been considered to play an essential role in the acquisition of novel information. Hence, the dopaminergic modulation of synaptic plasticity in the hippocampus has been widely studied. We examined how the D1 and D2 receptors influenced the mGluR5-mediated synaptic plasticity of the temporoammonic-CA1 synapses and showed that the dopaminergic modulation of the temporoammonic-CA1 synapses was expressed in various ways. Our findings suggest that the dopaminergic system in the hippocampal CA1 region regulates the long-term synaptic plasticity and processing of the novel information. The Korean Society for Brain and Neural Sciences 2022-12-31 2022-12-31 /pmc/articles/PMC9841748/ /pubmed/36631845 http://dx.doi.org/10.5607/en22028 Text en Copyright © Experimental Neurobiology 2022 https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Hye-Hyun Lee, Suk-Ho Ho, Won-Kyung Eom, Kisang Dopamine Receptor Supports the Potentiation of Intrinsic Excitability and Synaptic LTD in Temporoammonic-CA1 Synapse |
title | Dopamine Receptor Supports the Potentiation of Intrinsic Excitability and Synaptic LTD in Temporoammonic-CA1 Synapse |
title_full | Dopamine Receptor Supports the Potentiation of Intrinsic Excitability and Synaptic LTD in Temporoammonic-CA1 Synapse |
title_fullStr | Dopamine Receptor Supports the Potentiation of Intrinsic Excitability and Synaptic LTD in Temporoammonic-CA1 Synapse |
title_full_unstemmed | Dopamine Receptor Supports the Potentiation of Intrinsic Excitability and Synaptic LTD in Temporoammonic-CA1 Synapse |
title_short | Dopamine Receptor Supports the Potentiation of Intrinsic Excitability and Synaptic LTD in Temporoammonic-CA1 Synapse |
title_sort | dopamine receptor supports the potentiation of intrinsic excitability and synaptic ltd in temporoammonic-ca1 synapse |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841748/ https://www.ncbi.nlm.nih.gov/pubmed/36631845 http://dx.doi.org/10.5607/en22028 |
work_keys_str_mv | AT kimhyehyun dopaminereceptorsupportsthepotentiationofintrinsicexcitabilityandsynapticltdintemporoammonicca1synapse AT leesukho dopaminereceptorsupportsthepotentiationofintrinsicexcitabilityandsynapticltdintemporoammonicca1synapse AT howonkyung dopaminereceptorsupportsthepotentiationofintrinsicexcitabilityandsynapticltdintemporoammonicca1synapse AT eomkisang dopaminereceptorsupportsthepotentiationofintrinsicexcitabilityandsynapticltdintemporoammonicca1synapse |