Inflammation of Actinic Keratoses Induced by Combination of Carboplatin and Paclitaxel: Two Case Reports

The observations of a beneficial effect of 5-fluorouracil-induced actinic keratoses (AK) inflammation led to the development of topical fluorouracil, a product registered for the management of AK. A conscientious surveillance of AK inflammation during chemotherapy may conceivably lead to the develop...

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Autores principales: Baglama, Špela Šuler, Trajber Horvat, Anja, Peteln, Irena, Jemec, Gregor Borut Ernst
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841798/
https://www.ncbi.nlm.nih.gov/pubmed/36655062
http://dx.doi.org/10.1159/000528128
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author Baglama, Špela Šuler
Trajber Horvat, Anja
Peteln, Irena
Jemec, Gregor Borut Ernst
author_facet Baglama, Špela Šuler
Trajber Horvat, Anja
Peteln, Irena
Jemec, Gregor Borut Ernst
author_sort Baglama, Špela Šuler
collection PubMed
description The observations of a beneficial effect of 5-fluorouracil-induced actinic keratoses (AK) inflammation led to the development of topical fluorouracil, a product registered for the management of AK. A conscientious surveillance of AK inflammation during chemotherapy may conceivably lead to the development of further drugs for treatment of AK. A number of other chemotherapeutics have thus been linked to similar reactions without ensuing development. Here, we describe two further cases linking chemotherapy with carboplatin and paclitaxel to possible anti-AK effects, identifying them as potential treatments. Whether multidrug chemotherapy leads to stronger AK inflammation or cure AK more successfully is currently unknown.
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spelling pubmed-98417982023-01-17 Inflammation of Actinic Keratoses Induced by Combination of Carboplatin and Paclitaxel: Two Case Reports Baglama, Špela Šuler Trajber Horvat, Anja Peteln, Irena Jemec, Gregor Borut Ernst Case Rep Dermatol Case Report The observations of a beneficial effect of 5-fluorouracil-induced actinic keratoses (AK) inflammation led to the development of topical fluorouracil, a product registered for the management of AK. A conscientious surveillance of AK inflammation during chemotherapy may conceivably lead to the development of further drugs for treatment of AK. A number of other chemotherapeutics have thus been linked to similar reactions without ensuing development. Here, we describe two further cases linking chemotherapy with carboplatin and paclitaxel to possible anti-AK effects, identifying them as potential treatments. Whether multidrug chemotherapy leads to stronger AK inflammation or cure AK more successfully is currently unknown. S. Karger AG 2022-12-07 /pmc/articles/PMC9841798/ /pubmed/36655062 http://dx.doi.org/10.1159/000528128 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Baglama, Špela Šuler
Trajber Horvat, Anja
Peteln, Irena
Jemec, Gregor Borut Ernst
Inflammation of Actinic Keratoses Induced by Combination of Carboplatin and Paclitaxel: Two Case Reports
title Inflammation of Actinic Keratoses Induced by Combination of Carboplatin and Paclitaxel: Two Case Reports
title_full Inflammation of Actinic Keratoses Induced by Combination of Carboplatin and Paclitaxel: Two Case Reports
title_fullStr Inflammation of Actinic Keratoses Induced by Combination of Carboplatin and Paclitaxel: Two Case Reports
title_full_unstemmed Inflammation of Actinic Keratoses Induced by Combination of Carboplatin and Paclitaxel: Two Case Reports
title_short Inflammation of Actinic Keratoses Induced by Combination of Carboplatin and Paclitaxel: Two Case Reports
title_sort inflammation of actinic keratoses induced by combination of carboplatin and paclitaxel: two case reports
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841798/
https://www.ncbi.nlm.nih.gov/pubmed/36655062
http://dx.doi.org/10.1159/000528128
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