Frequency modulation stimulated Raman scattering scheme for real-time background correction with a single light source

A frequency modulation (FM) scheme for stimulated Raman scattering (SRS) is presented with a single fiber-based light source. Pulse-to-pulse wavelength-switching allows real-time subtraction of parasitic signals leaving only the resonant SRS signal with a noise reduction of up to 30 % compared to di...

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Detalles Bibliográficos
Autores principales: Wallmeier, Kristin, Würthwein, Thomas, Lemberger, Nick, Brinkmann, Maximilian, Hellwig, Tim, Fallnich, Carsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optica Publishing Group 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841997/
https://www.ncbi.nlm.nih.gov/pubmed/36698676
http://dx.doi.org/10.1364/BOE.476513
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author Wallmeier, Kristin
Würthwein, Thomas
Lemberger, Nick
Brinkmann, Maximilian
Hellwig, Tim
Fallnich, Carsten
author_facet Wallmeier, Kristin
Würthwein, Thomas
Lemberger, Nick
Brinkmann, Maximilian
Hellwig, Tim
Fallnich, Carsten
author_sort Wallmeier, Kristin
collection PubMed
description A frequency modulation (FM) scheme for stimulated Raman scattering (SRS) is presented with a single fiber-based light source. Pulse-to-pulse wavelength-switching allows real-time subtraction of parasitic signals leaving only the resonant SRS signal with a noise reduction of up to 30 % compared to digital subtraction schemes, leading effectively to a contrast improvement by a factor of up to 8.3. The wide tuning range of the light source from 1500 cm(−1) to 3000 cm(−1) and the possibility to separately adjust the resonant and the nonresonant wavenumber for every specimen allow to investigate a variety of samples with high contrast and high signal-to-noise ratio, e. g., for medical diagnostics.
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spelling pubmed-98419972023-01-24 Frequency modulation stimulated Raman scattering scheme for real-time background correction with a single light source Wallmeier, Kristin Würthwein, Thomas Lemberger, Nick Brinkmann, Maximilian Hellwig, Tim Fallnich, Carsten Biomed Opt Express Article A frequency modulation (FM) scheme for stimulated Raman scattering (SRS) is presented with a single fiber-based light source. Pulse-to-pulse wavelength-switching allows real-time subtraction of parasitic signals leaving only the resonant SRS signal with a noise reduction of up to 30 % compared to digital subtraction schemes, leading effectively to a contrast improvement by a factor of up to 8.3. The wide tuning range of the light source from 1500 cm(−1) to 3000 cm(−1) and the possibility to separately adjust the resonant and the nonresonant wavenumber for every specimen allow to investigate a variety of samples with high contrast and high signal-to-noise ratio, e. g., for medical diagnostics. Optica Publishing Group 2022-12-19 /pmc/articles/PMC9841997/ /pubmed/36698676 http://dx.doi.org/10.1364/BOE.476513 Text en Published by Optica Publishing Group under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Wallmeier, Kristin
Würthwein, Thomas
Lemberger, Nick
Brinkmann, Maximilian
Hellwig, Tim
Fallnich, Carsten
Frequency modulation stimulated Raman scattering scheme for real-time background correction with a single light source
title Frequency modulation stimulated Raman scattering scheme for real-time background correction with a single light source
title_full Frequency modulation stimulated Raman scattering scheme for real-time background correction with a single light source
title_fullStr Frequency modulation stimulated Raman scattering scheme for real-time background correction with a single light source
title_full_unstemmed Frequency modulation stimulated Raman scattering scheme for real-time background correction with a single light source
title_short Frequency modulation stimulated Raman scattering scheme for real-time background correction with a single light source
title_sort frequency modulation stimulated raman scattering scheme for real-time background correction with a single light source
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841997/
https://www.ncbi.nlm.nih.gov/pubmed/36698676
http://dx.doi.org/10.1364/BOE.476513
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