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Long‐term daily oral administration of intestinal permeation enhancers is safe and effective in mice

Although protein drugs are powerful biologic therapeutics, they cannot be delivered orally because their large size and hydrophilicity limit their absorption across the intestinal epithelium. One potential solution is the incorporation of permeation enhancers into oral protein formulations; however,...

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Detalles Bibliográficos
Autores principales: Fein, Katherine C., Gleeson, John P., Cochran, Kyle, Lamson, Nicholas G., Doerfler, Rose, Melamed, Jilian R., Whitehead, Kathryn A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842030/
https://www.ncbi.nlm.nih.gov/pubmed/36684095
http://dx.doi.org/10.1002/btm2.10342