Splice‐switch oligonucleotide‐based combinatorial platform prioritizes synthetic lethal targets CHK1 and BRD4 against MYC‐driven hepatocellular carcinoma

Deregulation of MYC is among the most frequent oncogenic drivers in hepatocellular carcinoma (HCC). Unfortunately, the clinical success of MYC‐targeted therapies is limited. Synthetic lethality offers an alternative therapeutic strategy by leveraging on vulnerabilities in tumors with MYC deregulatio...

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Detalles Bibliográficos
Autores principales: Thng, Dexter Kai Hao, Toh, Tan Boon, Pigini, Paolo, Hooi, Lissa, Dan, Yock Young, Chow, Pierce Kah‐Hoe, Bonney, Glenn Kunnath, Rashid, Masturah Bte Mohd Abdul, Guccione, Ernesto, Wee, Dave Keng Boon, Chow, Edward Kai‐Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842033/
https://www.ncbi.nlm.nih.gov/pubmed/36684069
http://dx.doi.org/10.1002/btm2.10363

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