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Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy

Green chemistry has been a growing multidisciplinary field in recent years showing great promise in biomedical applications, especially for cancer therapy. Chitosan (CS) is an abundant biopolymer derived from chitin and is present in insects and fungi. This polysaccharide has favorable characteristi...

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Autores principales: Ashrafizadeh, Milad, Hushmandi, Kiavash, Mirzaei, Sepideh, Bokaie, Saied, Bigham, Ashkan, Makvandi, Pooyan, Rabiee, Navid, Thakur, Vijay Kumar, Kumar, Alan Prem, Sharifi, Esmaeel, Varma, Rajender S., Aref, Amir Reza, Wojnilowicz, Marcin, Zarrabi, Ali, Karimi‐Maleh, Hassan, Voelcker, Nicolas H., Mostafavi, Ebrahim, Orive, Gorka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842052/
https://www.ncbi.nlm.nih.gov/pubmed/36684100
http://dx.doi.org/10.1002/btm2.10325
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author Ashrafizadeh, Milad
Hushmandi, Kiavash
Mirzaei, Sepideh
Bokaie, Saied
Bigham, Ashkan
Makvandi, Pooyan
Rabiee, Navid
Thakur, Vijay Kumar
Kumar, Alan Prem
Sharifi, Esmaeel
Varma, Rajender S.
Aref, Amir Reza
Wojnilowicz, Marcin
Zarrabi, Ali
Karimi‐Maleh, Hassan
Voelcker, Nicolas H.
Mostafavi, Ebrahim
Orive, Gorka
author_facet Ashrafizadeh, Milad
Hushmandi, Kiavash
Mirzaei, Sepideh
Bokaie, Saied
Bigham, Ashkan
Makvandi, Pooyan
Rabiee, Navid
Thakur, Vijay Kumar
Kumar, Alan Prem
Sharifi, Esmaeel
Varma, Rajender S.
Aref, Amir Reza
Wojnilowicz, Marcin
Zarrabi, Ali
Karimi‐Maleh, Hassan
Voelcker, Nicolas H.
Mostafavi, Ebrahim
Orive, Gorka
author_sort Ashrafizadeh, Milad
collection PubMed
description Green chemistry has been a growing multidisciplinary field in recent years showing great promise in biomedical applications, especially for cancer therapy. Chitosan (CS) is an abundant biopolymer derived from chitin and is present in insects and fungi. This polysaccharide has favorable characteristics, including biocompatibility, biodegradability, and ease of modification by enzymes and chemicals. CS‐based nanoparticles (CS‐NPs) have shown potential in the treatment of cancer and other diseases, affording targeted delivery and overcoming drug resistance. The current review emphasizes on the application of CS‐NPs for the delivery of a chemotherapeutic agent, doxorubicin (DOX), in cancer therapy as they promote internalization of DOX in cancer cells and prevent the activity of P‐glycoprotein (P‐gp) to reverse drug resistance. These nanoarchitectures can provide co‐delivery of DOX with antitumor agents such as curcumin and cisplatin to induce synergistic cancer therapy. Furthermore, co‐loading of DOX with siRNA, shRNA, and miRNA can suppress tumor progression and provide chemosensitivity. Various nanostructures, including lipid‐, carbon‐, polymeric‐ and metal‐based nanoparticles, are modifiable with CS for DOX delivery, while functionalization of CS‐NPs with ligands such as hyaluronic acid promotes selectivity toward tumor cells and prevents DOX resistance. The CS‐NPs demonstrate high encapsulation efficiency and due to protonation of amine groups of CS, pH‐sensitive release of DOX can occur. Furthermore, redox‐ and light‐responsive CS‐NPs have been prepared for DOX delivery in cancer treatment. Leveraging these characteristics and in view of the biocompatibility of CS‐NPs, we expect to soon see significant progress towards clinical translation.
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spelling pubmed-98420522023-01-19 Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy Ashrafizadeh, Milad Hushmandi, Kiavash Mirzaei, Sepideh Bokaie, Saied Bigham, Ashkan Makvandi, Pooyan Rabiee, Navid Thakur, Vijay Kumar Kumar, Alan Prem Sharifi, Esmaeel Varma, Rajender S. Aref, Amir Reza Wojnilowicz, Marcin Zarrabi, Ali Karimi‐Maleh, Hassan Voelcker, Nicolas H. Mostafavi, Ebrahim Orive, Gorka Bioeng Transl Med Review Articles Green chemistry has been a growing multidisciplinary field in recent years showing great promise in biomedical applications, especially for cancer therapy. Chitosan (CS) is an abundant biopolymer derived from chitin and is present in insects and fungi. This polysaccharide has favorable characteristics, including biocompatibility, biodegradability, and ease of modification by enzymes and chemicals. CS‐based nanoparticles (CS‐NPs) have shown potential in the treatment of cancer and other diseases, affording targeted delivery and overcoming drug resistance. The current review emphasizes on the application of CS‐NPs for the delivery of a chemotherapeutic agent, doxorubicin (DOX), in cancer therapy as they promote internalization of DOX in cancer cells and prevent the activity of P‐glycoprotein (P‐gp) to reverse drug resistance. These nanoarchitectures can provide co‐delivery of DOX with antitumor agents such as curcumin and cisplatin to induce synergistic cancer therapy. Furthermore, co‐loading of DOX with siRNA, shRNA, and miRNA can suppress tumor progression and provide chemosensitivity. Various nanostructures, including lipid‐, carbon‐, polymeric‐ and metal‐based nanoparticles, are modifiable with CS for DOX delivery, while functionalization of CS‐NPs with ligands such as hyaluronic acid promotes selectivity toward tumor cells and prevents DOX resistance. The CS‐NPs demonstrate high encapsulation efficiency and due to protonation of amine groups of CS, pH‐sensitive release of DOX can occur. Furthermore, redox‐ and light‐responsive CS‐NPs have been prepared for DOX delivery in cancer treatment. Leveraging these characteristics and in view of the biocompatibility of CS‐NPs, we expect to soon see significant progress towards clinical translation. John Wiley & Sons, Inc. 2022-09-13 /pmc/articles/PMC9842052/ /pubmed/36684100 http://dx.doi.org/10.1002/btm2.10325 Text en © 2022 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Articles
Ashrafizadeh, Milad
Hushmandi, Kiavash
Mirzaei, Sepideh
Bokaie, Saied
Bigham, Ashkan
Makvandi, Pooyan
Rabiee, Navid
Thakur, Vijay Kumar
Kumar, Alan Prem
Sharifi, Esmaeel
Varma, Rajender S.
Aref, Amir Reza
Wojnilowicz, Marcin
Zarrabi, Ali
Karimi‐Maleh, Hassan
Voelcker, Nicolas H.
Mostafavi, Ebrahim
Orive, Gorka
Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy
title Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy
title_full Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy
title_fullStr Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy
title_full_unstemmed Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy
title_short Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy
title_sort chitosan‐based nanoscale systems for doxorubicin delivery: exploring biomedical application in cancer therapy
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842052/
https://www.ncbi.nlm.nih.gov/pubmed/36684100
http://dx.doi.org/10.1002/btm2.10325
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