The missing link between genetic association and regulatory function

The genetic basis of most traits is highly polygenic and dominated by non-coding alleles. It is widely assumed that such alleles exert small regulatory effects on the expression of cis-linked genes. However, despite the availability of gene expression and epigenomic datasets, few variant-to-gene lin...

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Detalles Bibliográficos
Autores principales: Connally, Noah J, Nazeen, Sumaiya, Lee, Daniel, Shi, Huwenbo, Stamatoyannopoulos, John, Chun, Sung, Cotsapas, Chris, Cassa, Christopher A, Sunyaev, Shamil R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842386/
https://www.ncbi.nlm.nih.gov/pubmed/36515579
http://dx.doi.org/10.7554/eLife.74970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842386/
https://www.ncbi.nlm.nih.gov/pubmed/36515579
http://dx.doi.org/10.7554/eLife.74970

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