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Chronic Gastric Ulcer Healing Actions of the Aqueous Extracts of Staple Plant Foods of the North-West, Adamawa, and West Regions of Cameroon

AIM: This study is aimed at establishing phenolic compound profile and assessing the possible antiulcer activities of aqueous extracts of some staple plant foods from the West and North-West regions of Cameroon against chronic gastric ulcer models in rats. MATERIALS AND METHODS: Phenolic constituent...

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Autores principales: Mikwangock, Hauberline Domegne, Tamfu, Alfred Ngenge, Amang, André Perfusion, Siwe, Gael Tchokomeni, Mezui, Christophe, Kucukaydin, Selcuk, Enow-Orock, Enonchong George, Tan, Paul Vernyuy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842419/
https://www.ncbi.nlm.nih.gov/pubmed/36654868
http://dx.doi.org/10.1155/2023/2657278
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author Mikwangock, Hauberline Domegne
Tamfu, Alfred Ngenge
Amang, André Perfusion
Siwe, Gael Tchokomeni
Mezui, Christophe
Kucukaydin, Selcuk
Enow-Orock, Enonchong George
Tan, Paul Vernyuy
author_facet Mikwangock, Hauberline Domegne
Tamfu, Alfred Ngenge
Amang, André Perfusion
Siwe, Gael Tchokomeni
Mezui, Christophe
Kucukaydin, Selcuk
Enow-Orock, Enonchong George
Tan, Paul Vernyuy
author_sort Mikwangock, Hauberline Domegne
collection PubMed
description AIM: This study is aimed at establishing phenolic compound profile and assessing the possible antiulcer activities of aqueous extracts of some staple plant foods from the West and North-West regions of Cameroon against chronic gastric ulcer models in rats. MATERIALS AND METHODS: Phenolic constituents of extracts were evaluated using HPLC-DAD. Aqueous extracts of Corchorus olitorius, Solanum nigrum, Vigna unguiculata, Triumfetta pentandra, “nkui” spices, and “yellow soup” spices were tested at two doses (200 and 400 mg/kg). After treatments, animals were sacrificed, healing percentage and antioxidant status (catalase, superoxide dismutase, and glutathione peroxidase) were evaluated, and histological examination of gastric mucosa was realized. RESULTS: HPLC-DAD revealed that p-hydroxybenzoic and protocatechuic acids were the phenolic compound present in all extracts. Oral administration of extracts (200 and 400 mg/kg) significantly reduced ulcer surface value and significantly increased mucus production compared to the control groups (p < 0.05). Histological study supported the observed healing activity of different extracts characterized by a reduced inflammatory response. Moreover, administration of aqueous extracts increased the activity of antioxidant enzymes. CONCLUSION: This study revealed that aqueous extracts of Solanum nigrum, Corchorus olitorius, Vigna unguiculata, Triumfetta pentandra, “yellow soup” spices, and “nkui” spices possess healing antiulcer effects against models of gastric ulcers. The antiulcer mechanisms involved may include increase of gastric mucus production and improvement of the antioxidant activity of gastric tissue. These activities may be due to the phenolic compounds identified in the extracts, especially p-hydroxybenzoic and protocatechuic acids present in all extracts and with known antioxidant, cytoprotective, and healing properties. However, all the diets may promote the healing process of chronic ulcers caused by excessive alcohol consumption/stress.
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spelling pubmed-98424192023-01-17 Chronic Gastric Ulcer Healing Actions of the Aqueous Extracts of Staple Plant Foods of the North-West, Adamawa, and West Regions of Cameroon Mikwangock, Hauberline Domegne Tamfu, Alfred Ngenge Amang, André Perfusion Siwe, Gael Tchokomeni Mezui, Christophe Kucukaydin, Selcuk Enow-Orock, Enonchong George Tan, Paul Vernyuy Biomed Res Int Research Article AIM: This study is aimed at establishing phenolic compound profile and assessing the possible antiulcer activities of aqueous extracts of some staple plant foods from the West and North-West regions of Cameroon against chronic gastric ulcer models in rats. MATERIALS AND METHODS: Phenolic constituents of extracts were evaluated using HPLC-DAD. Aqueous extracts of Corchorus olitorius, Solanum nigrum, Vigna unguiculata, Triumfetta pentandra, “nkui” spices, and “yellow soup” spices were tested at two doses (200 and 400 mg/kg). After treatments, animals were sacrificed, healing percentage and antioxidant status (catalase, superoxide dismutase, and glutathione peroxidase) were evaluated, and histological examination of gastric mucosa was realized. RESULTS: HPLC-DAD revealed that p-hydroxybenzoic and protocatechuic acids were the phenolic compound present in all extracts. Oral administration of extracts (200 and 400 mg/kg) significantly reduced ulcer surface value and significantly increased mucus production compared to the control groups (p < 0.05). Histological study supported the observed healing activity of different extracts characterized by a reduced inflammatory response. Moreover, administration of aqueous extracts increased the activity of antioxidant enzymes. CONCLUSION: This study revealed that aqueous extracts of Solanum nigrum, Corchorus olitorius, Vigna unguiculata, Triumfetta pentandra, “yellow soup” spices, and “nkui” spices possess healing antiulcer effects against models of gastric ulcers. The antiulcer mechanisms involved may include increase of gastric mucus production and improvement of the antioxidant activity of gastric tissue. These activities may be due to the phenolic compounds identified in the extracts, especially p-hydroxybenzoic and protocatechuic acids present in all extracts and with known antioxidant, cytoprotective, and healing properties. However, all the diets may promote the healing process of chronic ulcers caused by excessive alcohol consumption/stress. Hindawi 2023-01-09 /pmc/articles/PMC9842419/ /pubmed/36654868 http://dx.doi.org/10.1155/2023/2657278 Text en Copyright © 2023 Hauberline Domegne Mikwangock et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mikwangock, Hauberline Domegne
Tamfu, Alfred Ngenge
Amang, André Perfusion
Siwe, Gael Tchokomeni
Mezui, Christophe
Kucukaydin, Selcuk
Enow-Orock, Enonchong George
Tan, Paul Vernyuy
Chronic Gastric Ulcer Healing Actions of the Aqueous Extracts of Staple Plant Foods of the North-West, Adamawa, and West Regions of Cameroon
title Chronic Gastric Ulcer Healing Actions of the Aqueous Extracts of Staple Plant Foods of the North-West, Adamawa, and West Regions of Cameroon
title_full Chronic Gastric Ulcer Healing Actions of the Aqueous Extracts of Staple Plant Foods of the North-West, Adamawa, and West Regions of Cameroon
title_fullStr Chronic Gastric Ulcer Healing Actions of the Aqueous Extracts of Staple Plant Foods of the North-West, Adamawa, and West Regions of Cameroon
title_full_unstemmed Chronic Gastric Ulcer Healing Actions of the Aqueous Extracts of Staple Plant Foods of the North-West, Adamawa, and West Regions of Cameroon
title_short Chronic Gastric Ulcer Healing Actions of the Aqueous Extracts of Staple Plant Foods of the North-West, Adamawa, and West Regions of Cameroon
title_sort chronic gastric ulcer healing actions of the aqueous extracts of staple plant foods of the north-west, adamawa, and west regions of cameroon
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842419/
https://www.ncbi.nlm.nih.gov/pubmed/36654868
http://dx.doi.org/10.1155/2023/2657278
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