Creation of Philadelphia chromosome by CRISPR/Cas9-mediated double cleavages on BCR and ABL1 genes as a model for initial event in leukemogenesis

The Philadelphia (Ph) chromosome was the first translocation identified in leukemia. It is supposed to be generated by aberrant ligation between two DNA double-strand breaks (DSBs) at the BCR gene located on chromosome 9q34 and the ABL1 gene located on chromosome 22q11. Thus, mimicking the initiatio...

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Detalles Bibliográficos
Autores principales: Tamai, Minori, Fujisawa, Shinichi, Nguyen, Thao T. T., Komatsu, Chiaki, Kagami, Keiko, Kamimoto, Kenji, Omachi, Kohei, Kasai, Shin, Harama, Daisuke, Watanabe, Atsushi, Akahane, Koshi, Goi, Kumiko, Naka, Kazuhito, Kaname, Tadashi, Teshima, Takanori, Inukai, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842507/
https://www.ncbi.nlm.nih.gov/pubmed/35999358
http://dx.doi.org/10.1038/s41417-022-00522-w

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