Pharmacological targeting of CBP/p300 drives a redox/autophagy axis leading to senescence-induced growth arrest in non-small cell lung cancer cells

p300/CBP histone acetyltransferases (HAT) are critical transcription coactivators involved in multiple cellular activities. They act at multiple levels in non-small cell lung carcinoma (NSCLC) and appear, therefore, as promising druggable targets. Herein, we investigated the biological effects of A-...

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Detalles Bibliográficos
Autores principales: Ansari, Mohammad Salik Zeya, Stagni, Venturina, Iuzzolino, Angela, Rotili, Dante, Mai, Antonello, Del Bufalo, Donatella, Lavia, Patrizia, Degrassi, Francesca, Trisciuoglio, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842509/
https://www.ncbi.nlm.nih.gov/pubmed/36117234
http://dx.doi.org/10.1038/s41417-022-00524-8

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