Ablation of Adar1 in myeloid cells imprints a global antiviral state in the lung and heightens early immunity against SARS-CoV-2

Under normal homeostatic conditions, self-double-stranded RNA (self-dsRNA) is modified by adenosine deaminase acting on RNA 1 (ADAR1) to prevent the induction of a type I interferon-mediated inflammatory cascade. Antigen-presenting cells (APCs) sense pathogen-associated molecular patterns, such as d...

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Detalles Bibliográficos
Autores principales: Adamska, Julia Z., Verma, Rohit, Gupta, Shakti, Hagan, Thomas, Wimmers, Florian, Floyd, Katharine, Li, Qin, Valore, Erika V., Wang, Yanli, Trisal, Meera, Vilches-Moure, José G., Subramaniam, Shankar, Walkley, Carl R., Suthar, Mehul S., Li, Jin Billy, Pulendran, Bali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842623/
https://www.ncbi.nlm.nih.gov/pubmed/36732946
http://dx.doi.org/10.1016/j.celrep.2023.112038

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