Hyperaminoacidemia induces pancreatic α cell proliferation via synergism between the mTORC1 and CaSR-Gq signaling pathways

Glucagon has emerged as a key regulator of extracellular amino acid (AA) homeostasis. Insufficient glucagon signaling results in hyperaminoacidemia, which drives adaptive proliferation of glucagon-producing α cells. Aside from mammalian target of rapamycin complex 1 (mTORC1), the role of other AA se...

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Detalles Bibliográficos
Autores principales: Gong, Yulong, Yang, Bingyuan, Zhang, Dingdong, Zhang, Yue, Tang, Zihan, Yang, Liu, Coate, Katie C., Yin, Linlin, Covington, Brittney A., Patel, Ravi S., Siv, Walter A., Sellick, Katelyn, Shou, Matthew, Chang, Wenhan, Danielle Dean, E., Powers, Alvin C., Chen, Wenbiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842633/
https://www.ncbi.nlm.nih.gov/pubmed/36646689
http://dx.doi.org/10.1038/s41467-022-35705-4

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