Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity

In Parkinson’s disease and other synucleinopathies, the elevation of α-synuclein phosphorylated at Serine129 (pS129) is a widely cited marker of pathology. However, the physiological role for pS129 has remained undefined. Here we use multiple approaches to show for the first time that pS129 function...

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Detalles Bibliográficos
Autores principales: Ramalingam, Nagendran, Jin, Shan-Xue, Moors, Tim E., Fonseca-Ornelas, Luis, Shimanaka, Kazuma, Lei, Shi, Cam, Hugh P., Watson, Aurelia Hays, Brontesi, Lisa, Ding, Lai, Hacibaloglu, Dinc Yasat, Jiang, Haiyang, Choi, Se Joon, Kanter, Ellen, Liu, Lei, Bartels, Tim, Nuber, Silke, Sulzer, David, Mosharov, Eugene V., Chen, Weisheng V., Li, Shaomin, Selkoe, Dennis J., Dettmer, Ulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842642/
https://www.ncbi.nlm.nih.gov/pubmed/36646701
http://dx.doi.org/10.1038/s41531-023-00444-w

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