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Deep mutational scanning of essential bacterial proteins can guide antibiotic development

Deep mutational scanning is a powerful approach to investigate a wide variety of research questions including protein function and stability. Here, we perform deep mutational scanning on three essential E. coli proteins (FabZ, LpxC and MurA) involved in cell envelope synthesis using high-throughput...

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Detalles Bibliográficos
Autores principales:	Dewachter, Liselot, Brooks, Aaron N., Noon, Katherine, Cialek, Charlotte, Clark-ElSayed, Alia, Schalck, Thomas, Krishnamurthy, Nandini, Versées, Wim, Vranken, Wim, Michiels, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842644/ https://www.ncbi.nlm.nih.gov/pubmed/36646716 http://dx.doi.org/10.1038/s41467-023-35940-3

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