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Breastfeeding is not a risk factor for clinical severity in Autism spectrum disorder in children from the ELENA cohort

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that results from a complex interaction between genes and environment. Breastfeeding (BF) is thought to promote healthy cognitive development, and a body of research has suggested that it may also protect against ASD. Our objectives wer...

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Autores principales: Peries, Marianne, Duhr, Fanny, Picot, Marie-Christine, Heude, Barbara, Bernard, Jonathan Y., Baghdadli, Amaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842713/
https://www.ncbi.nlm.nih.gov/pubmed/36646708
http://dx.doi.org/10.1038/s41598-022-27040-x
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author Peries, Marianne
Duhr, Fanny
Picot, Marie-Christine
Heude, Barbara
Bernard, Jonathan Y.
Baghdadli, Amaria
author_facet Peries, Marianne
Duhr, Fanny
Picot, Marie-Christine
Heude, Barbara
Bernard, Jonathan Y.
Baghdadli, Amaria
author_sort Peries, Marianne
collection PubMed
description Autism spectrum disorder (ASD) is a neurodevelopmental disorder that results from a complex interaction between genes and environment. Breastfeeding (BF) is thought to promote healthy cognitive development, and a body of research has suggested that it may also protect against ASD. Our objectives were to identify the relationship between the initiation and duration of BF and the severity of clinical presentation in ASD. Data were collected from 243 children with a confirmed diagnosis of ASD followed in the ELENA cohort. Clinical severity was measured according to multiple dimensions using standardised tools. The frequency of the initiation of BF was comparable to that of the general population and the rate of children still being breastfed at six months of age was higher. Our results did not indicate a contribution of initiation or duration of BF to the prevention of clinical severity of ASD. We discuss our results in the light of possible methodological limitations of previous reports of an association between BF and ASD. Clinical Trial Registration: NCT02625116.
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spelling pubmed-98427132023-01-18 Breastfeeding is not a risk factor for clinical severity in Autism spectrum disorder in children from the ELENA cohort Peries, Marianne Duhr, Fanny Picot, Marie-Christine Heude, Barbara Bernard, Jonathan Y. Baghdadli, Amaria Sci Rep Article Autism spectrum disorder (ASD) is a neurodevelopmental disorder that results from a complex interaction between genes and environment. Breastfeeding (BF) is thought to promote healthy cognitive development, and a body of research has suggested that it may also protect against ASD. Our objectives were to identify the relationship between the initiation and duration of BF and the severity of clinical presentation in ASD. Data were collected from 243 children with a confirmed diagnosis of ASD followed in the ELENA cohort. Clinical severity was measured according to multiple dimensions using standardised tools. The frequency of the initiation of BF was comparable to that of the general population and the rate of children still being breastfed at six months of age was higher. Our results did not indicate a contribution of initiation or duration of BF to the prevention of clinical severity of ASD. We discuss our results in the light of possible methodological limitations of previous reports of an association between BF and ASD. Clinical Trial Registration: NCT02625116. Nature Publishing Group UK 2023-01-16 /pmc/articles/PMC9842713/ /pubmed/36646708 http://dx.doi.org/10.1038/s41598-022-27040-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Peries, Marianne
Duhr, Fanny
Picot, Marie-Christine
Heude, Barbara
Bernard, Jonathan Y.
Baghdadli, Amaria
Breastfeeding is not a risk factor for clinical severity in Autism spectrum disorder in children from the ELENA cohort
title Breastfeeding is not a risk factor for clinical severity in Autism spectrum disorder in children from the ELENA cohort
title_full Breastfeeding is not a risk factor for clinical severity in Autism spectrum disorder in children from the ELENA cohort
title_fullStr Breastfeeding is not a risk factor for clinical severity in Autism spectrum disorder in children from the ELENA cohort
title_full_unstemmed Breastfeeding is not a risk factor for clinical severity in Autism spectrum disorder in children from the ELENA cohort
title_short Breastfeeding is not a risk factor for clinical severity in Autism spectrum disorder in children from the ELENA cohort
title_sort breastfeeding is not a risk factor for clinical severity in autism spectrum disorder in children from the elena cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842713/
https://www.ncbi.nlm.nih.gov/pubmed/36646708
http://dx.doi.org/10.1038/s41598-022-27040-x
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