Dual guide RNA-mediated concurrent C&G-to-T&A and A&T-to-G&C conversions using CRISPR base editors

Base editing tools enable precise genome modifications, disease modeling, and promising gene therapy. However, many human genetic diseases are elicited by multi-nucleotide variants (MNVs) with heterogeneous substitutions at the same genomic locus. Based on the adenine and cytosine base editors, dual...

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Detalles Bibliográficos
Autores principales: Zhao, Yuting, Li, Min, Liu, Jie, Xue, Xiaowen, Zhong, Jingli, Lin, Jianxiang, Ye, Bo, Chen, Jun, Qiao, Yunbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842798/
https://www.ncbi.nlm.nih.gov/pubmed/36698964
http://dx.doi.org/10.1016/j.csbj.2022.12.055

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