Multi-modal artificial intelligence for the combination of automated 3D breast ultrasound and mammograms in a population of women with predominantly dense breasts

OBJECTIVES: To assess the stand-alone and combined performance of artificial intelligence (AI) detection systems for digital mammography (DM) and automated 3D breast ultrasound (ABUS) in detecting breast cancer in women with dense breasts. METHODS: 430 paired cases of DM and ABUS examinations from a...

Descripción completa

Detalles Bibliográficos
Autores principales: Tan, Tao, Rodriguez-Ruiz, Alejandro, Zhang, Tianyu, Xu, Lin, Beets-Tan, Regina G. H., Shen, Yingzhao, Karssemeijer, Nico, Xu, Jun, Mann, Ritse M., Bao, Lingyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842825/
https://www.ncbi.nlm.nih.gov/pubmed/36645507
http://dx.doi.org/10.1186/s13244-022-01352-y
_version_ 1784870232977833984
author Tan, Tao
Rodriguez-Ruiz, Alejandro
Zhang, Tianyu
Xu, Lin
Beets-Tan, Regina G. H.
Shen, Yingzhao
Karssemeijer, Nico
Xu, Jun
Mann, Ritse M.
Bao, Lingyun
author_facet Tan, Tao
Rodriguez-Ruiz, Alejandro
Zhang, Tianyu
Xu, Lin
Beets-Tan, Regina G. H.
Shen, Yingzhao
Karssemeijer, Nico
Xu, Jun
Mann, Ritse M.
Bao, Lingyun
author_sort Tan, Tao
collection PubMed
description OBJECTIVES: To assess the stand-alone and combined performance of artificial intelligence (AI) detection systems for digital mammography (DM) and automated 3D breast ultrasound (ABUS) in detecting breast cancer in women with dense breasts. METHODS: 430 paired cases of DM and ABUS examinations from a Asian population with dense breasts were retrospectively collected. All cases were analyzed by two AI systems, one for DM exams and one for ABUS exams. A selected subset (n = 152) was read by four radiologists. The performance of AI systems was based on analysis of the area under the receiver operating characteristic curve (AUC). The maximum Youden’s index and its associated sensitivity and specificity were also reported for each AI systems. Detection performance of human readers in the subcohort of the reader study was measured in terms of sensitivity and specificity. RESULTS: The performance of the AI systems in a multi-modal setting was significantly better when the weights of AI-DM and AI-ABUS were 0.25 and 0.75, respectively, than each system individually in a single-modal setting (AUC-AI-Multimodal = 0.865; AUC-AI-DM = 0.832, p = 0.026; AUC-AI-ABUS = 0.841, p = 0.041). The maximum Youden’s index for AI-Multimodal was 0.707 (sensitivity = 79.4%, specificity = 91.2%). In the subcohort that underwent human reading, the panel of four readers achieved a sensitivity of 93.2% and specificity of 32.7%. AI-multimodal achieves superior or equal sensitivity as single human readers at the same specificity operating points on the ROC curve. CONCLUSION: Multimodal (ABUS + DM) AI systems for detecting breast cancer in women with dense breasts are a potential solution for breast screening in radiologist-scarce regions.
format Online
Article
Text
id pubmed-9842825
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Springer Vienna
record_format MEDLINE/PubMed
spelling pubmed-98428252023-01-18 Multi-modal artificial intelligence for the combination of automated 3D breast ultrasound and mammograms in a population of women with predominantly dense breasts Tan, Tao Rodriguez-Ruiz, Alejandro Zhang, Tianyu Xu, Lin Beets-Tan, Regina G. H. Shen, Yingzhao Karssemeijer, Nico Xu, Jun Mann, Ritse M. Bao, Lingyun Insights Imaging Original Article OBJECTIVES: To assess the stand-alone and combined performance of artificial intelligence (AI) detection systems for digital mammography (DM) and automated 3D breast ultrasound (ABUS) in detecting breast cancer in women with dense breasts. METHODS: 430 paired cases of DM and ABUS examinations from a Asian population with dense breasts were retrospectively collected. All cases were analyzed by two AI systems, one for DM exams and one for ABUS exams. A selected subset (n = 152) was read by four radiologists. The performance of AI systems was based on analysis of the area under the receiver operating characteristic curve (AUC). The maximum Youden’s index and its associated sensitivity and specificity were also reported for each AI systems. Detection performance of human readers in the subcohort of the reader study was measured in terms of sensitivity and specificity. RESULTS: The performance of the AI systems in a multi-modal setting was significantly better when the weights of AI-DM and AI-ABUS were 0.25 and 0.75, respectively, than each system individually in a single-modal setting (AUC-AI-Multimodal = 0.865; AUC-AI-DM = 0.832, p = 0.026; AUC-AI-ABUS = 0.841, p = 0.041). The maximum Youden’s index for AI-Multimodal was 0.707 (sensitivity = 79.4%, specificity = 91.2%). In the subcohort that underwent human reading, the panel of four readers achieved a sensitivity of 93.2% and specificity of 32.7%. AI-multimodal achieves superior or equal sensitivity as single human readers at the same specificity operating points on the ROC curve. CONCLUSION: Multimodal (ABUS + DM) AI systems for detecting breast cancer in women with dense breasts are a potential solution for breast screening in radiologist-scarce regions. Springer Vienna 2023-01-16 /pmc/articles/PMC9842825/ /pubmed/36645507 http://dx.doi.org/10.1186/s13244-022-01352-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Tan, Tao
Rodriguez-Ruiz, Alejandro
Zhang, Tianyu
Xu, Lin
Beets-Tan, Regina G. H.
Shen, Yingzhao
Karssemeijer, Nico
Xu, Jun
Mann, Ritse M.
Bao, Lingyun
Multi-modal artificial intelligence for the combination of automated 3D breast ultrasound and mammograms in a population of women with predominantly dense breasts
title Multi-modal artificial intelligence for the combination of automated 3D breast ultrasound and mammograms in a population of women with predominantly dense breasts
title_full Multi-modal artificial intelligence for the combination of automated 3D breast ultrasound and mammograms in a population of women with predominantly dense breasts
title_fullStr Multi-modal artificial intelligence for the combination of automated 3D breast ultrasound and mammograms in a population of women with predominantly dense breasts
title_full_unstemmed Multi-modal artificial intelligence for the combination of automated 3D breast ultrasound and mammograms in a population of women with predominantly dense breasts
title_short Multi-modal artificial intelligence for the combination of automated 3D breast ultrasound and mammograms in a population of women with predominantly dense breasts
title_sort multi-modal artificial intelligence for the combination of automated 3d breast ultrasound and mammograms in a population of women with predominantly dense breasts
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842825/
https://www.ncbi.nlm.nih.gov/pubmed/36645507
http://dx.doi.org/10.1186/s13244-022-01352-y
work_keys_str_mv AT tantao multimodalartificialintelligenceforthecombinationofautomated3dbreastultrasoundandmammogramsinapopulationofwomenwithpredominantlydensebreasts
AT rodriguezruizalejandro multimodalartificialintelligenceforthecombinationofautomated3dbreastultrasoundandmammogramsinapopulationofwomenwithpredominantlydensebreasts
AT zhangtianyu multimodalartificialintelligenceforthecombinationofautomated3dbreastultrasoundandmammogramsinapopulationofwomenwithpredominantlydensebreasts
AT xulin multimodalartificialintelligenceforthecombinationofautomated3dbreastultrasoundandmammogramsinapopulationofwomenwithpredominantlydensebreasts
AT beetstanreginagh multimodalartificialintelligenceforthecombinationofautomated3dbreastultrasoundandmammogramsinapopulationofwomenwithpredominantlydensebreasts
AT shenyingzhao multimodalartificialintelligenceforthecombinationofautomated3dbreastultrasoundandmammogramsinapopulationofwomenwithpredominantlydensebreasts
AT karssemeijernico multimodalartificialintelligenceforthecombinationofautomated3dbreastultrasoundandmammogramsinapopulationofwomenwithpredominantlydensebreasts
AT xujun multimodalartificialintelligenceforthecombinationofautomated3dbreastultrasoundandmammogramsinapopulationofwomenwithpredominantlydensebreasts
AT mannritsem multimodalartificialintelligenceforthecombinationofautomated3dbreastultrasoundandmammogramsinapopulationofwomenwithpredominantlydensebreasts
AT baolingyun multimodalartificialintelligenceforthecombinationofautomated3dbreastultrasoundandmammogramsinapopulationofwomenwithpredominantlydensebreasts