Expanded NK cells used for adoptive cell therapy maintain diverse clonality and contain long-lived memory-like NK cell populations

Multiple clinical trials exploring the potential of adoptive natural killer (NK) cell therapy for cancer have employed ex vivo expansion using feeder cells to obtain large numbers of NK cells. We have previously utilized the rhesus macaque model to clonally track the NK cell progeny of barcode-trans...

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Detalles Bibliográficos
Autores principales: Allan, David S.J., Wu, Chuanfeng, Mortlock, Ryland D., Chakraborty, Mala, Rezvani, Katayoun, Davidson-Moncada, Jan K., Dunbar, Cynthia E., Childs, Richard W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9842935/
https://www.ncbi.nlm.nih.gov/pubmed/36699615
http://dx.doi.org/10.1016/j.omto.2022.12.006

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