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Placental transport of Erythromycin and its effect on placental inflammatory factors

OBJECTIVE: Erythromycin is used for prevention and control of infectious perinatal morbidity. It has been hypothesised that erythromycin crosses the placenta and has an effect on the production of placental inflammatory factors. We evaluated the transport of erythromycin in an ex-vivo closed perfusi...

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Autores principales: Elbiss, Hassan, Osman, Nawal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843005/
https://www.ncbi.nlm.nih.gov/pubmed/36694753
http://dx.doi.org/10.12669/pjms.39.1.6683
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author Elbiss, Hassan
Osman, Nawal
author_facet Elbiss, Hassan
Osman, Nawal
author_sort Elbiss, Hassan
collection PubMed
description OBJECTIVE: Erythromycin is used for prevention and control of infectious perinatal morbidity. It has been hypothesised that erythromycin crosses the placenta and has an effect on the production of placental inflammatory factors. We evaluated the transport of erythromycin in an ex-vivo closed perfusion system of the placenta and determined its effect on the production of placenta inflammatory markers. METHODS: In 2013, a prospective basic science study was conducted at the placental laboratory of College of Medicine and Health Sciences, United Arab Emirates. Six term placentas from uncomplicated pregnancies were studied using the ex-vivo dual closed-loop human placental cotyledon perfusion technique. Erythromycin was added to the perfusate in the maternal compartment. Samples were obtained from the maternal and fetal up to 240 minutes. RESULTS: The reference antipyrine was detected in the fetal circulation in the first 15 minutes after addition of the drug. At this point the mean antipyrine was 49.90±2.10μg/ml in the maternal perfusate and 7.1±1.56μg/ml in fetal perfusate. The fetal and maternal concentration became similar at 120 minutes. The transfer of antipyrine from maternal to fetal compartment was 98.66%. The differences between perfusion groups were non-significant that indicates the perfusion of placentas was comparable. After media exchange in both sides, erythromycin was added to the maternal perfusate. The experimental period of four hours was continued with medium circulation on both maternal and fetal circulation. The concentration of erythromycin decreased in the maternal circuit by 36.4% and increased in the fetal circuit by 65%. The concentration of IL-6 in the maternal circuit was normal. CONCLUSION: Erythromycin crossed the placenta and did not inhibit the production of IL-6. Future studies are needed concerning neonatal adverse effects and the development of antibiotic resistance.
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spelling pubmed-98430052023-01-23 Placental transport of Erythromycin and its effect on placental inflammatory factors Elbiss, Hassan Osman, Nawal Pak J Med Sci Original Article OBJECTIVE: Erythromycin is used for prevention and control of infectious perinatal morbidity. It has been hypothesised that erythromycin crosses the placenta and has an effect on the production of placental inflammatory factors. We evaluated the transport of erythromycin in an ex-vivo closed perfusion system of the placenta and determined its effect on the production of placenta inflammatory markers. METHODS: In 2013, a prospective basic science study was conducted at the placental laboratory of College of Medicine and Health Sciences, United Arab Emirates. Six term placentas from uncomplicated pregnancies were studied using the ex-vivo dual closed-loop human placental cotyledon perfusion technique. Erythromycin was added to the perfusate in the maternal compartment. Samples were obtained from the maternal and fetal up to 240 minutes. RESULTS: The reference antipyrine was detected in the fetal circulation in the first 15 minutes after addition of the drug. At this point the mean antipyrine was 49.90±2.10μg/ml in the maternal perfusate and 7.1±1.56μg/ml in fetal perfusate. The fetal and maternal concentration became similar at 120 minutes. The transfer of antipyrine from maternal to fetal compartment was 98.66%. The differences between perfusion groups were non-significant that indicates the perfusion of placentas was comparable. After media exchange in both sides, erythromycin was added to the maternal perfusate. The experimental period of four hours was continued with medium circulation on both maternal and fetal circulation. The concentration of erythromycin decreased in the maternal circuit by 36.4% and increased in the fetal circuit by 65%. The concentration of IL-6 in the maternal circuit was normal. CONCLUSION: Erythromycin crossed the placenta and did not inhibit the production of IL-6. Future studies are needed concerning neonatal adverse effects and the development of antibiotic resistance. Professional Medical Publications 2023 /pmc/articles/PMC9843005/ /pubmed/36694753 http://dx.doi.org/10.12669/pjms.39.1.6683 Text en Copyright: © Pakistan Journal of Medical Sciences https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0 (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Elbiss, Hassan
Osman, Nawal
Placental transport of Erythromycin and its effect on placental inflammatory factors
title Placental transport of Erythromycin and its effect on placental inflammatory factors
title_full Placental transport of Erythromycin and its effect on placental inflammatory factors
title_fullStr Placental transport of Erythromycin and its effect on placental inflammatory factors
title_full_unstemmed Placental transport of Erythromycin and its effect on placental inflammatory factors
title_short Placental transport of Erythromycin and its effect on placental inflammatory factors
title_sort placental transport of erythromycin and its effect on placental inflammatory factors
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843005/
https://www.ncbi.nlm.nih.gov/pubmed/36694753
http://dx.doi.org/10.12669/pjms.39.1.6683
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