ODF2L acts as a synthetic lethal partner with WEE1 inhibition in epithelial ovarian cancer models

WEE1 has emerged as an attractive target in epithelial ovarian cancer (EOC), but how EOC cells may alter their sensitivity to WEE1 inhibition remains unclear. Here, through a cell cycle machinery–related gene RNAi screen, we found that targeting outer dense fiber of sperm tails 2–like (ODF2L) was a...

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Detalles Bibliográficos
Autores principales: Li, Jie, Lu, Jingyi, Xu, Manman, Yang, Shiyu, Yu, Tiantian, Zheng, Cuimiao, Huang, Xi, Pan, Yuwen, Chen, Yangyang, Long, Junming, Zhang, Chunyu, Huang, Hua, Dai, Qingyuan, Li, Bo, Wang, Wei, Yao, Shuzhong, Pan, Chaoyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843051/
https://www.ncbi.nlm.nih.gov/pubmed/36378528
http://dx.doi.org/10.1172/JCI161544

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