Superenhancer activation of KLHDC8A drives glioma ciliation and hedgehog signaling

Glioblastoma ranks among the most aggressive and lethal of all human cancers. Self-renewing, highly tumorigenic glioblastoma stem cells (GSCs) contribute to therapeutic resistance and maintain cellular heterogeneity. Here, we interrogated superenhancer landscapes of primary glioblastoma specimens an...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Derrick, Gimple, Ryan C., Wu, Xujia, Prager, Briana C., Qiu, Zhixin, Wu, Qiulian, Daggubati, Vikas, Mariappan, Aruljothi, Gopalakrishnan, Jay, Sarkisian, Matthew R., Raleigh, David R., Rich, Jeremy N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843063/
https://www.ncbi.nlm.nih.gov/pubmed/36394953
http://dx.doi.org/10.1172/JCI163592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843063/
https://www.ncbi.nlm.nih.gov/pubmed/36394953
http://dx.doi.org/10.1172/JCI163592

Ejemplares similares