Cargando…

Superenhancer activation of KLHDC8A drives glioma ciliation and hedgehog signaling

Glioblastoma ranks among the most aggressive and lethal of all human cancers. Self-renewing, highly tumorigenic glioblastoma stem cells (GSCs) contribute to therapeutic resistance and maintain cellular heterogeneity. Here, we interrogated superenhancer landscapes of primary glioblastoma specimens an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Derrick, Gimple, Ryan C., Wu, Xujia, Prager, Briana C., Qiu, Zhixin, Wu, Qiulian, Daggubati, Vikas, Mariappan, Aruljothi, Gopalakrishnan, Jay, Sarkisian, Matthew R., Raleigh, David R., Rich, Jeremy N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843063/ https://www.ncbi.nlm.nih.gov/pubmed/36394953 http://dx.doi.org/10.1172/JCI163592

Ejemplares similares

Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals
por: Findakly, Sarah, et al.
Publicado: (2020)

Superenhancers: Novel opportunities for nanowire optoelectronics
por: Khudiyev, Tural, et al.
Publicado: (2014)

FSMP-08. TARGETING PYRIMIDINE SYNTHESIS ACCENTUATES MOLECULAR THERAPY RESPONSE IN GLIOBLASTOMA STEM CELLS
por: Yang, Kailin, et al.
Publicado: (2021)

ADAR1-mediated RNA editing links ganglioside catabolism to glioblastoma stem cell maintenance
por: Jiang, Li, et al.
Publicado: (2022)

Superenhancer–transcription factor regulatory network in malignant tumors
por: Liang, Yuan, et al.
Publicado: (2021)

Editorial: Epigenetic and metabolic regulation of primary and metastatic brain cancers
por: Gimple, Ryan C., et al.
Publicado: (2023)

Upregulation of KLHDC4 Predicts a Poor Prognosis in Human Nasopharyngeal Carcinoma
por: Lian, Yi-Fan, et al.
Publicado: (2016)

NaviSE: superenhancer navigator integrating epigenomics signal algebra
por: Ascensión, Alex M., et al.
Publicado: (2017)

DDRE-02. SMOOTHENED-ACTIVATING LIPIDS DRIVE RESISTANCE TO CDK4/6 INHIBITION IN HEDGEHOG-ASSOCIATED MEDULLOBLASTOMA
por: Daggubati, Vikas, et al.
Publicado: (2021)

Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway
por: Findakly, Sarah, et al.
Publicado: (2020)

EMBR-16. SMOOTHENED-ACTIVATING LIPIDS DRIVE RESISTANCE TO CDK4/6 INHIBITION IN HEDGEHOG-ASSOCIATED MEDULLOBLASTOMA
por: Daggubati, Vikas, et al.
Publicado: (2021)

KLHDC10 Deficiency Protects Mice against TNFα-Induced Systemic Inflammation
por: Yamaguchi, Namiko, et al.
Publicado: (2016)

eRNAs and Superenhancer lncRNAs Are Functional in Human Prostate Cancer
por: Zhang, Xiaona, et al.
Publicado: (2020)

Myeloma-specific superenhancers affect genes of biological and clinical relevance in myeloma
por: Jia, Yunlu, et al.
Publicado: (2021)

Superenhancers as master gene regulators and novel therapeutic targets in brain tumors
por: Zhuang, Hai-Hui, et al.
Publicado: (2023)

Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma
por: Sen, Arko, et al.
Publicado: (2022)

Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers
por: Loft, Anne, et al.
Publicado: (2015)

INO80 governs superenhancer-mediated oncogenic transcription and tumor growth in melanoma
por: Zhou, Bingying, et al.
Publicado: (2016)

Recurrent Superenhancer of the Oncogene POU5F1B in Colorectal Cancers
por: Tao, Han-chuan, et al.
Publicado: (2021)

Trends and challenges in modeling glioma using 3D human brain organoids
por: Mariappan, Aruljothi, et al.
Publicado: (2020)

Hedgehog target genes regulate lipid metabolism to drive basal cell carcinoma and medulloblastoma
por: Daggubati, Vikas, et al.
Publicado: (2023)

KLHDC8A Expression in Association with Macrophage Infiltration and Oxidative Stress Predicts Unfavorable Prognosis for Glioma
por: Cheng, Tong, et al.
Publicado: (2022)

Superenhancer reprogramming drives a B-cell–epithelial transition and high-risk leukemia
por: Hu, Yeguang, et al.
Publicado: (2016)

Sorting nexin 10 sustains PDGF receptor signaling in glioblastoma stem cells via endosomal protein sorting
por: Gimple, Ryan C., et al.
Publicado: (2023)

Retracted: KLHDC8A Expression in Association with Macrophage Infiltration and Oxidative Stress Predicts Unfavorable Prognosis for Glioma
por: Longevity, Oxidative Medicine and Cellular
Publicado: (2023)

Defining the transcriptional control of pediatric AML highlights RARA as a superenhancer-regulated druggable dependency
por: Perez, Monika W., et al.
Publicado: (2021)

Advances in lung adenocarcinoma: A novel perspective on prognoses and immune responses of CENPO as an oncogenic superenhancer
por: Shi, Tongdong, et al.
Publicado: (2023)

The BRD4 Inhibitor dBET57 Exerts Anticancer Effects by Targeting Superenhancer-Related Genes in Neuroblastoma
por: Jia, Si-Qi, et al.
Publicado: (2022)

LncRNA INHEG promotes glioma stem cell maintenance and tumorigenicity through regulating rRNA 2’-O-methylation
por: Liu, Lihui, et al.
Publicado: (2023)

ILF2 Contributes to Hyperproliferation of Keratinocytes and Skin Inflammation in a KLHDC7B-DT-Dependent Manner in Psoriasis
por: Yin, Xiran, et al.
Publicado: (2022)

Cul5-type Ubiquitin Ligase KLHDC1 Contributes to the Elimination of Truncated SELENOS Produced by Failed UGA/Sec Decoding
por: Okumura, Fumihiko, et al.
Publicado: (2020)

Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions
por: Tang, Min, et al.
Publicado: (2020)

Superenhancer drives a tumor-specific splicing variant of MARCO to promote triple-negative breast cancer progression
por: Yang, Yun-Song, et al.
Publicado: (2022)

Mechanism and evolutionary origins of alanine-tail C-degron recognition by E3 ligases Pirh2 and CRL2-KLHDC10
por: Patil, Pratik Rajendra, et al.
Publicado: (2023)

Targeting Glioma Stem Cells through Combined BMI1 and EZH2 Inhibition
por: Jin, Xun, et al.
Publicado: (2017)

Translocations at 8q24 juxtapose MYC with genes that harbor superenhancers resulting in overexpression and poor prognosis in myeloma patients
por: Walker, B A, et al.
Publicado: (2014)

New SigD-regulated genes identified in the rhizobacterium Bacillus amyloliquefaciens FZB42
por: Fan, Ben, et al.
Publicado: (2016)

ELF3 activated by a superenhancer and an autoregulatory feedback loop is required for high-level HLA-C expression on extravillous trophoblasts
por: Li, Qin, et al.
Publicado: (2021)

Lactate induced up‐regulation of KLHDC8A (Kelch domain‐containing 8A) contributes to the proliferation, migration and apoptosis of human glioma cells
por: Zhu, Xiaolong, et al.
Publicado: (2020)

Targeting EYA2 tyrosine phosphatase activity in glioblastoma stem cells induces mitotic catastrophe
por: Zhang, Guoxin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_treh802u97o5lnprdb1odek6pf