Cargando…

Identification and characterization of novel carboxyl ester lipase gene variants in patients with different subtypes of diabetes

INTRODUCTION: Mutations of CEL gene were first reported to cause a new type of maturity-onset diabetes of the young (MODY) denoted as MODY8 and then were also found in patients with type 1 (T1D) and type 2 diabetes (T2D). However, its genotype-phenotype relationship has not been fully determined and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Huixiao, Shu, Meng, Liu, Changmei, Zhao, Wanyi, Li, Qiu, Song, Yuling, Zhang, Ting, Chen, Xinyu, Shi, Yingzhou, Shi, Ping, Fang, Li, Wang, Runbo, Xu, Chao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843195/ https://www.ncbi.nlm.nih.gov/pubmed/36634979 http://dx.doi.org/10.1136/bmjdrc-2022-003127

Ejemplares similares

hZnT8 (Slc30a8) Transgenic Mice That Overexpress the R325W Polymorph Have Reduced Islet Zn(2+) and Proinsulin Levels, Increased Glucose Tolerance After a High-Fat Diet, and Altered Levels of Pancreatic Zinc Binding Proteins
por: Li, Li, et al.
Publicado: (2017)

Rare Genetic Variants of Large Effect Influence Risk of Type 1 Diabetes
por: Forgetta, Vincenzo, et al.
Publicado: (2020)

Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians
por: Hwang, Joo-Yeon, et al.
Publicado: (2015)

Role of Established Type 2 Diabetes–Susceptibility Genetic Variants in a High Prevalence American Indian Population
por: Hanson, Robert L., et al.
Publicado: (2015)

Human serum metabolomic analysis reveals progression for high blood pressure in type 2 diabetes mellitus
por: Zhang, Yin, et al.
Publicado: (2021)

Polygenic Type 2 Diabetes Prediction at the Limit of Common Variant Detection
por: Vassy, Jason L., et al.
Publicado: (2014)

Sixty-Five Common Genetic Variants and Prediction of Type 2 Diabetes
por: Talmud, Philippa J., et al.
Publicado: (2015)

Genetic variants associated with beta-cell function and insulin sensitivity potentially influence bile acid metabolites and gestational diabetes mellitus in a Chinese population
por: Zhou, Qiulun, et al.
Publicado: (2021)

Deep Resequencing Unveils Genetic Architecture of ADIPOQ and Identifies a Novel Low-Frequency Variant Strongly Associated With Adiponectin Variation
por: Warren, Liling L., et al.
Publicado: (2012)

Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk
por: Marquez, Marcel, et al.
Publicado: (2012)

Lack of association of genetic variants for diabetic retinopathy in Taiwanese patients with diabetic nephropathy
por: Hsieh, Ai-Ru, et al.
Publicado: (2020)

Zinc-Associated Variant in SLC30A8 Gene Interacts With Gestational Weight Gain on Postpartum Glycemic Changes: A Longitudinal Study in Women With Prior Gestational Diabetes Mellitus
por: Wang, Tiange, et al.
Publicado: (2016)

Mitochondrial DNA Coding and Control Region Variants as Genetic Risk Factors for Type 2 Diabetes
por: Liou, Chia-Wei, et al.
Publicado: (2012)

Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity
por: Dimas, Antigone S., et al.
Publicado: (2014)

Genetic Variant at the GLUL Locus Predicts All-Cause Mortality in Patients With Type 2 Diabetes
por: Prudente, Sabrina, et al.
Publicado: (2015)

A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes
por: Mercader, Josep M., et al.
Publicado: (2017)

Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology
por: Lane, Jacqueline M., et al.
Publicado: (2016)

New clinical screening strategy to distinguish HNF1A variant-induced diabetes from young early-onset type 2 diabetes in a Chinese population
por: Ma, Yumin, et al.
Publicado: (2020)

Association Testing of Previously Reported Variants in a Large Case-Control Meta-analysis of Diabetic Nephropathy
por: Williams, Winfred W., et al.
Publicado: (2012)

Hyperglycemia and a Common Variant of GCKR Are Associated With the Levels of Eight Amino Acids in 9,369 Finnish Men
por: Stančáková, Alena, et al.
Publicado: (2012)

Fine Mapping and Functional Studies of Risk Variants for Type 1 Diabetes at Chromosome 16p13.13
por: Tomlinson, M. Joseph, et al.
Publicado: (2014)

Identification of candidate gene variants of monogenic diabetes using targeted panel sequencing in early onset diabetes patients
por: Lee, Dong-Hwa, et al.
Publicado: (2021)

No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels
por: Scott, Robert A., et al.
Publicado: (2012)

Association of G6PD variants with hemoglobin A1c and impact on diabetes diagnosis in East Asian individuals
por: Leong, Aaron, et al.
Publicado: (2020)

ABCC8 R1420H Loss-of-Function Variant in a Southwest American Indian Community: Association With Increased Birth Weight and Doubled Risk of Type 2 Diabetes
por: Baier, Leslie J., et al.
Publicado: (2015)

The ATP-Sensitive K(+) Channel ABCC8 S1369A Type 2 Diabetes Risk Variant Increases MgATPase Activity
por: Fatehi, Mohammad, et al.
Publicado: (2012)

Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the GIPR Region
por: Bowker, Nicholas, et al.
Publicado: (2021)

Consistent Directions of Effect for Established Type 2 Diabetes Risk Variants Across Populations: The Population Architecture using Genomics and Epidemiology (PAGE) Consortium
por: Haiman, Christopher A., et al.
Publicado: (2012)

A Gene-Family Analysis of 61 Genetic Variants in the Nicotinic Acetylcholine Receptor Genes for Insulin Resistance and Type 2 Diabetes in American Indians
por: Yang, Jingyun, et al.
Publicado: (2012)

The Gly(972)Arg Variant of Human IRS1 Gene Is Associated With Variation in Glomerular Filtration Rate Likely Through Impaired Insulin Receptor Signaling
por: Thameem, Farook, et al.
Publicado: (2012)

Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium
por: Palmer, Nicholette D., et al.
Publicado: (2015)

Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 That Confer Risk for Type 1 Diabetes
por: Ge, Yan, et al.
Publicado: (2016)

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants
por: Wood, Andrew R., et al.
Publicado: (2017)

A Genome-Wide Association Study Using a Custom Genotyping Array Identifies Variants in GPR158 Associated With Reduced Energy Expenditure in American Indians
por: Piaggi, Paolo, et al.
Publicado: (2017)

CREBRF missense variant rs373863828 has both direct and indirect effects on type 2 diabetes and fasting glucose in Polynesian peoples living in Samoa and Aotearoa New Zealand
por: Russell, Emily M, et al.
Publicado: (2022)

Immunoproteomic Profiling of Antiviral Antibodies in New-Onset Type 1 Diabetes Using Protein Arrays
por: Bian, Xiaofang, et al.
Publicado: (2016)

Association of high-sensitivity C-reactive protein and diabetic nephropathy in patients with type 2 diabetes: a Mendelian randomization study
por: Lin, Cheng-Chieh, et al.
Publicado: (2023)

Nontargeted and Targeted Metabolomic Profiling Reveals Novel Metabolite Biomarkers of Incident Diabetes in African Americans
por: Chen, Zsu-Zsu, et al.
Publicado: (2022)

Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation
por: Baig, Sonia, et al.
Publicado: (2020)

Molecular and clinical characteristics of monogenic diabetes mellitus in southern Chinese children with onset before 3 years of age
por: Lin, Yunting, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_mqbadu97sc81358hb9teh3o262