Radiation to all macroscopic sites of tumor permits greater systemic antitumor response to in situ vaccination

BACKGROUND: The antitumor effects of external beam radiation therapy (EBRT) are mediated, in part, by an immune response. We have reported that a single fraction of 12 Gy EBRT combined with intratumoral anti-GD2 hu14.18-IL2 immunocytokine (IC) generates an effective in situ vaccine (ISV) against GD2...

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Detalles Bibliográficos
Autores principales: Carlson, Peter M, Patel, Ravi B, Birstler, Jen, Rodriquez, Matthew, Sun, Claire, Erbe, Amy K, Bates, Amber M, Marsh, Ian, Grudzinski, Joseph, Hernandez, Reinier, Pieper, Alexander A, Feils, Arika S, Rakhmilevich, Alexander L, Weichert, Jamey P, Bednarz, Bryan P, Sondel, Paul M, Morris, Zachary S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Oncolytic and Local Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843201/
https://www.ncbi.nlm.nih.gov/pubmed/36639155
http://dx.doi.org/10.1136/jitc-2022-005463

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