Target concentration achievement for efficacy and safety of patients with osteosarcoma treated with high-dose methotrexate based on individual pharmacokinetics: A retrospective study

In the high-dose methotrexate (HD-MTX) treatment of patients with osteosarcoma, a dose-adjustment method using individual pharmacokinetic parameters (PK method) to optimize the concentration was developed in 2010. However, to the best of our knowledge, the clinical usefulness of the PK method has no...

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Autores principales: Nagamine, Ayumu, Araki, Takuya, Yashima, Hideaki, Kamimura, Akane, Shiraishi, Takumi, Yanagawa, Takashi, Obayashi, Kyoko, Yamamoto, Koujirou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843304/
https://www.ncbi.nlm.nih.gov/pubmed/36688106
http://dx.doi.org/10.3892/ol.2022.13656

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