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The inhibitor of κB kinase β (IKKβ) phosphorylates IκBα twice in a single binding event through a sequential mechanism

Phosphorylation of Inhibitor of κB (IκB) proteins by IκB Kinase β (IKKβ) leads to IκB degradation and subsequent activation of nuclear factor κB transcription factors. Of particular interest is the IKKβ-catalyzed phosphorylation of IκBα residues Ser(32) and Ser(36) within a conserved destruction box...

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Detalles Bibliográficos
Autores principales:	Stephenson, Anthony A., Taggart, David J., Xu, Guozhou, Fowler, Jason D., Wu, Hao, Suo, Zucai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843440/ https://www.ncbi.nlm.nih.gov/pubmed/36528060 http://dx.doi.org/10.1016/j.jbc.2022.102796

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