Nonclinical pharmacokinetics and biodistribution of VSV-GP using methods to decouple input drug disposition and viral replication

Viral replication places oncolytic viruses (OVs) in a unique niche in the field of drug pharmacokinetics (PK) as their self-amplification obscures exposure-response relationships. Moreover, standard bioanalytical techniques are unable to distinguish the input from replicated drug products. Here, we...

Descripción completa

Detalles Bibliográficos
Autores principales: Dambra, Richard, Matter, Andrea, Graca, Kaitlynn, Akhand, Saeed Salehin, Mehta, Saurin, Bell-Cohn, Ashlee, Swenson, Joyce M., Abid, Sadia, Xin, Dongyue, Lewis, Cedric, Coyle, Luke, Wang, Min, Bunosso, Kathleen, Maugiri, Michelle, Ruiz, Richard, Cirillo, Corey M., Fogal, Birgit, Grimaldi, Christine, Vigil, Adam, Wood, Charles, Ashour, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843450/
https://www.ncbi.nlm.nih.gov/pubmed/36700123
http://dx.doi.org/10.1016/j.omtm.2022.12.013

Ejemplares similares

Ejemplares similares