Change of intracellular calcium level causes acute neurotoxicity by antisense oligonucleotides via CSF route

Antisense oligonucleotides (ASOs) are promising therapeutics for intractable central nervous system (CNS) diseases. For this clinical application, neurotoxicity is one of the critical limitations. Therefore, an evaluation of this neurotoxicity from a behavioral perspective is important to reveal sym...

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Detalles Bibliográficos
Autores principales: Jia, Chunyan, Lei Mon, Su Su, Yang, Ying, Katsuyama, Maho, Yoshida-Tanaka, Kie, Nagata, Tetsuya, Yoshioka, Kotaro, Yokota, Takanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843489/
https://www.ncbi.nlm.nih.gov/pubmed/36700050
http://dx.doi.org/10.1016/j.omtn.2022.12.010

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