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Cholecystectomy reduces the severity of subsequent idiopathic acute pancreatitis
BACKGROUND: Acute pancreatitis (AP) is a common digestive system disease, and its incidence is increasing year by year. Although some clinical studies have indicated that cholecystectomy can reduce the risk of recurrent pancreatitis after acute biliary pancreatitis (ABP), it is not clear whether cho...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843515/ https://www.ncbi.nlm.nih.gov/pubmed/36153928 http://dx.doi.org/10.4103/sjg.sjg_441_21 |
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author | Lei, Jing Xu, Feng Cao, Haiyan Zhou, Zhihang He, Song |
author_facet | Lei, Jing Xu, Feng Cao, Haiyan Zhou, Zhihang He, Song |
author_sort | Lei, Jing |
collection | PubMed |
description | BACKGROUND: Acute pancreatitis (AP) is a common digestive system disease, and its incidence is increasing year by year. Although some clinical studies have indicated that cholecystectomy can reduce the risk of recurrent pancreatitis after acute biliary pancreatitis (ABP), it is not clear whether cholecystectomy would affect the severity of subsequent AP. METHODS: In this study, we combined computed tomography scoring index (CTSI), bedside index for severity in AP (BISAP), and clinical manifestations grading of AP with propensity score matching (PSM), after correction for baseline confounding factors, to respectively explore the influence of cholecystectomy on the severity of subsequent pancreatitis in 527 AP patients. RESULTS: The results showed that ABP (231/527) is more common in female patients and elderly patients (P < 0.001). Age, amylase, creatinine, blood urea nitrogen, and aspartate aminotransferase levels of patients with ABP at admission were higher than those of non-biliary pancreatitis (296/527), and the levels of albumin, hematocrit, and blood glucose were lower (P < 0.050). Further, compared with the unresected group (458/527), patients after cholecystectomy (69/527) had less white blood cells and higher level of albumin (P < 0.050). Patients had lower clinical manifestation grade (P = 0.019) and CTSI grade (P < 0.008) after cholecystectomy. After PSM correction, there was no difference in biochemical parameters between the cholecystectomy group and the non-cholecystectomy group, but differences in clinical manifestation grade (P = 0.039) and CTSI grade (P = 0.013) remained. We also found that cholecystectomy reduced the frequency of biliary pancreatitis (30.4% vs. 45.9%, P < 0.050). Finally, we found that cholecystectomy could reduce the severity of subsequent idiopathic AP. CONCLUSION: Cholecystectomy could reduce the severity of subsequent idiopathic AP and the frequency of biliary pancreatitis. |
format | Online Article Text |
id | pubmed-9843515 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-98435152023-01-18 Cholecystectomy reduces the severity of subsequent idiopathic acute pancreatitis Lei, Jing Xu, Feng Cao, Haiyan Zhou, Zhihang He, Song Saudi J Gastroenterol Original Article BACKGROUND: Acute pancreatitis (AP) is a common digestive system disease, and its incidence is increasing year by year. Although some clinical studies have indicated that cholecystectomy can reduce the risk of recurrent pancreatitis after acute biliary pancreatitis (ABP), it is not clear whether cholecystectomy would affect the severity of subsequent AP. METHODS: In this study, we combined computed tomography scoring index (CTSI), bedside index for severity in AP (BISAP), and clinical manifestations grading of AP with propensity score matching (PSM), after correction for baseline confounding factors, to respectively explore the influence of cholecystectomy on the severity of subsequent pancreatitis in 527 AP patients. RESULTS: The results showed that ABP (231/527) is more common in female patients and elderly patients (P < 0.001). Age, amylase, creatinine, blood urea nitrogen, and aspartate aminotransferase levels of patients with ABP at admission were higher than those of non-biliary pancreatitis (296/527), and the levels of albumin, hematocrit, and blood glucose were lower (P < 0.050). Further, compared with the unresected group (458/527), patients after cholecystectomy (69/527) had less white blood cells and higher level of albumin (P < 0.050). Patients had lower clinical manifestation grade (P = 0.019) and CTSI grade (P < 0.008) after cholecystectomy. After PSM correction, there was no difference in biochemical parameters between the cholecystectomy group and the non-cholecystectomy group, but differences in clinical manifestation grade (P = 0.039) and CTSI grade (P = 0.013) remained. We also found that cholecystectomy reduced the frequency of biliary pancreatitis (30.4% vs. 45.9%, P < 0.050). Finally, we found that cholecystectomy could reduce the severity of subsequent idiopathic AP. CONCLUSION: Cholecystectomy could reduce the severity of subsequent idiopathic AP and the frequency of biliary pancreatitis. Wolters Kluwer - Medknow 2022-05-09 /pmc/articles/PMC9843515/ /pubmed/36153928 http://dx.doi.org/10.4103/sjg.sjg_441_21 Text en Copyright: © 2022 Saudi Journal of Gastroenterology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Lei, Jing Xu, Feng Cao, Haiyan Zhou, Zhihang He, Song Cholecystectomy reduces the severity of subsequent idiopathic acute pancreatitis |
title | Cholecystectomy reduces the severity of subsequent idiopathic acute pancreatitis |
title_full | Cholecystectomy reduces the severity of subsequent idiopathic acute pancreatitis |
title_fullStr | Cholecystectomy reduces the severity of subsequent idiopathic acute pancreatitis |
title_full_unstemmed | Cholecystectomy reduces the severity of subsequent idiopathic acute pancreatitis |
title_short | Cholecystectomy reduces the severity of subsequent idiopathic acute pancreatitis |
title_sort | cholecystectomy reduces the severity of subsequent idiopathic acute pancreatitis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843515/ https://www.ncbi.nlm.nih.gov/pubmed/36153928 http://dx.doi.org/10.4103/sjg.sjg_441_21 |
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