Cargando…
IL‐33‐ST2 pathway regulates AECII transdifferentiation by targeting alveolar macrophage in a bronchopulmonary dysplasia mouse model
Evidence points to the indispensable function of alveolar macrophages (AMs) in normal lung development and tissue homeostasis. However, the importance of AMs in bronchopulmonary dysplasia (BPD) has not been elucidated. Here, we identified a significant role of abnormal AM proliferation and polarizat...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843522/ https://www.ncbi.nlm.nih.gov/pubmed/36573439 http://dx.doi.org/10.1111/jcmm.17654 |
_version_ | 1784870427684765696 |
---|---|
author | Zhu, Yue Yao, Hui‐ci Lu, Hong‐yan Hao, Xiao‐bo Xu, Su‐qing |
author_facet | Zhu, Yue Yao, Hui‐ci Lu, Hong‐yan Hao, Xiao‐bo Xu, Su‐qing |
author_sort | Zhu, Yue |
collection | PubMed |
description | Evidence points to the indispensable function of alveolar macrophages (AMs) in normal lung development and tissue homeostasis. However, the importance of AMs in bronchopulmonary dysplasia (BPD) has not been elucidated. Here, we identified a significant role of abnormal AM proliferation and polarization in alveolar dysplasia during BPD, which is closely related to the activation of the IL‐33‐ST2 pathway. Compared with the control BPD group, AMs depletion partially abolished the epithelialmesenchymal transition process of AECII and alleviated pulmonary differentiation arrest. In addition, IL‐33 or ST2 knockdown has protective effects against lung injury after hyperoxia, which is associated with reduced AM polarization and proliferation. The protective effect disappeared following reconstitution of AMs in injured IL‐33 knockdown mice, and the differentiation of lung epithelium was blocked again. In conclusion, the IL‐33‐ST2 pathway regulates AECII transdifferentiation by targeting AMs proliferation and polarization in BPD, which shows a novel strategy for manipulating the IL‐33–ST2‐AMs axis for the diagnosis and intervention of BPD. |
format | Online Article Text |
id | pubmed-9843522 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98435222023-01-23 IL‐33‐ST2 pathway regulates AECII transdifferentiation by targeting alveolar macrophage in a bronchopulmonary dysplasia mouse model Zhu, Yue Yao, Hui‐ci Lu, Hong‐yan Hao, Xiao‐bo Xu, Su‐qing J Cell Mol Med Short Communication Evidence points to the indispensable function of alveolar macrophages (AMs) in normal lung development and tissue homeostasis. However, the importance of AMs in bronchopulmonary dysplasia (BPD) has not been elucidated. Here, we identified a significant role of abnormal AM proliferation and polarization in alveolar dysplasia during BPD, which is closely related to the activation of the IL‐33‐ST2 pathway. Compared with the control BPD group, AMs depletion partially abolished the epithelialmesenchymal transition process of AECII and alleviated pulmonary differentiation arrest. In addition, IL‐33 or ST2 knockdown has protective effects against lung injury after hyperoxia, which is associated with reduced AM polarization and proliferation. The protective effect disappeared following reconstitution of AMs in injured IL‐33 knockdown mice, and the differentiation of lung epithelium was blocked again. In conclusion, the IL‐33‐ST2 pathway regulates AECII transdifferentiation by targeting AMs proliferation and polarization in BPD, which shows a novel strategy for manipulating the IL‐33–ST2‐AMs axis for the diagnosis and intervention of BPD. John Wiley and Sons Inc. 2022-12-27 /pmc/articles/PMC9843522/ /pubmed/36573439 http://dx.doi.org/10.1111/jcmm.17654 Text en © 2022 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Zhu, Yue Yao, Hui‐ci Lu, Hong‐yan Hao, Xiao‐bo Xu, Su‐qing IL‐33‐ST2 pathway regulates AECII transdifferentiation by targeting alveolar macrophage in a bronchopulmonary dysplasia mouse model |
title |
IL‐33‐ST2 pathway regulates AECII transdifferentiation by targeting alveolar macrophage in a bronchopulmonary dysplasia mouse model |
title_full |
IL‐33‐ST2 pathway regulates AECII transdifferentiation by targeting alveolar macrophage in a bronchopulmonary dysplasia mouse model |
title_fullStr |
IL‐33‐ST2 pathway regulates AECII transdifferentiation by targeting alveolar macrophage in a bronchopulmonary dysplasia mouse model |
title_full_unstemmed |
IL‐33‐ST2 pathway regulates AECII transdifferentiation by targeting alveolar macrophage in a bronchopulmonary dysplasia mouse model |
title_short |
IL‐33‐ST2 pathway regulates AECII transdifferentiation by targeting alveolar macrophage in a bronchopulmonary dysplasia mouse model |
title_sort | il‐33‐st2 pathway regulates aecii transdifferentiation by targeting alveolar macrophage in a bronchopulmonary dysplasia mouse model |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843522/ https://www.ncbi.nlm.nih.gov/pubmed/36573439 http://dx.doi.org/10.1111/jcmm.17654 |
work_keys_str_mv | AT zhuyue il33st2pathwayregulatesaeciitransdifferentiationbytargetingalveolarmacrophageinabronchopulmonarydysplasiamousemodel AT yaohuici il33st2pathwayregulatesaeciitransdifferentiationbytargetingalveolarmacrophageinabronchopulmonarydysplasiamousemodel AT luhongyan il33st2pathwayregulatesaeciitransdifferentiationbytargetingalveolarmacrophageinabronchopulmonarydysplasiamousemodel AT haoxiaobo il33st2pathwayregulatesaeciitransdifferentiationbytargetingalveolarmacrophageinabronchopulmonarydysplasiamousemodel AT xusuqing il33st2pathwayregulatesaeciitransdifferentiationbytargetingalveolarmacrophageinabronchopulmonarydysplasiamousemodel |