Experimental diabetes exacerbates autophagic flux impairment during myocardial I/R injury through calpain‐mediated cleavage of Atg5/LAMP2

To explore the role of autophagic flux in the increased susceptibility of the experimental diabetic heart to ischaemia‐reperfusion (I/R) injury, we established STZ‐induced diabetic mice and performed I/R. In vitro, neonatal mouse cardiomyocytes were subjected to high glucose and hypoxia/reoxygenatio...

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Detalles Bibliográficos
Autores principales: Guan, Lichun, Yu, Ziqin, Che, Zhimei, Zhang, Hang, Yu, Yong, Yang, Dicheng, Qian, Dewei, Chen, Ruizhen, Yu, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843523/
https://www.ncbi.nlm.nih.gov/pubmed/36562207
http://dx.doi.org/10.1111/jcmm.17642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843523/
https://www.ncbi.nlm.nih.gov/pubmed/36562207
http://dx.doi.org/10.1111/jcmm.17642

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