Optical coherence tomography-guided early postoperative management of XEN Gel implant

This interventional case series demonstrates the usefulness of anterior segment optical coherence tomography (AS-OCT) in guiding early postoperative management following XEN45 Gel Stent implantation, in conjunction with intraocular pressure (IOP) readings and slit lamp findings. Three primary open-angle glaucoma patients undergoing XEN45 Gel Stent implantation were included. Two patients received early postoperative needling because the IOP was not low enough and AS-OCT revealed that the XEN stent orifice was trapped by the Tenon's capsule. Immediately after needling, the distal tip of the XEN stent was freed and connected to a cystic space with significant IOP reduction. The third patient suffered from abrupt bleb flattening on the 5(th) postoperative day following XEN stent implantation. AS-OCT revealed internal occlusion of the XEN stent with exudative material, which resolved spontaneously after intensifying topical steroids with improved bleb functioning 2 days later. AS-OCT provides in-depth microscopic evaluation of the XEN stent and its relationship with surrounding tissue. This information is helpful in identifying causes of impaired outflow, determining the timing, and effect of needling intervention in eyes with inadequate bleb functioning or IOP control, especially during the early postoperative period.