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The Association between Exposure to Air Pollution and Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis

BACKGROUND: This systematic review and meta-analysis aimed to overview the observational studies on the association of exposure to air pollution and type 1 diabetes mellitus (T1DM). MATERIALS AND METHODS: Based on PRISMA guidelines, we systematically reviewed the databases of PubMed, Scopus, Embase,...

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Autores principales: Mozafarian, Nafiseh, Hashemipour, Mahin, Yazdi, Maryam, Hani Tabaei Zavareh, Mohsen, Hovsepian, Silva, Heidarpour, Maryam, Taheri, Ensiyeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843592/
https://www.ncbi.nlm.nih.gov/pubmed/36660754
http://dx.doi.org/10.4103/abr.abr_80_21
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author Mozafarian, Nafiseh
Hashemipour, Mahin
Yazdi, Maryam
Hani Tabaei Zavareh, Mohsen
Hovsepian, Silva
Heidarpour, Maryam
Taheri, Ensiyeh
author_facet Mozafarian, Nafiseh
Hashemipour, Mahin
Yazdi, Maryam
Hani Tabaei Zavareh, Mohsen
Hovsepian, Silva
Heidarpour, Maryam
Taheri, Ensiyeh
author_sort Mozafarian, Nafiseh
collection PubMed
description BACKGROUND: This systematic review and meta-analysis aimed to overview the observational studies on the association of exposure to air pollution and type 1 diabetes mellitus (T1DM). MATERIALS AND METHODS: Based on PRISMA guidelines, we systematically reviewed the databases of PubMed, Scopus, Embase, and Web of Science databases to determine the association of air pollution exposure and T1DM. Quality assessment of the papers was evaluated using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist for observational studies. The odds ratios (OR) and their 95% confidence intervals (CI) were calculated to assess the strength of the associations between air pollutants (gases and particulate matter air pollutants including PM10, PM2.5, NO2, volatile organic compound, SO4, SO2, O3) and T1DM. RESULTS: Out of 385 initially identified papers, 6 studies were used for this meta-analysis. Fixed effects meta-analysis showed a significant association between per 10 μg/m(3) increase in O3 and PM2.5 exposures with the increased risk of T1DM (3 studies, OR = 1.51, 95% CI: 1.26, 1.80, I(2) = 83.5% for O3 and two studies, OR = 1.03, 95% CI: 1.01, 1.05, I(2) = 76.3% for PM2.5). There was no evidence of association between increased risk of T1DM and exposure to PM10 (OR = 1.02, 95% CI: 0.99–1.06, I(2) = 59.4%), SO4 (OR = 1.16, 95% CI: 0.91–1.49, I(2) = 93.8%), SO2 (OR = 0.94, 95% CI: 0.83–1.06, I(2) = 85.0%), and NO2 (OR = 0.995,95% CI: 1.05–1.04, I(2) = 24.7%). CONCLUSION: Recent publications indicated that exposure to ozone and PM2.5 may be a risk factor for T1DM. However, due to limited available studies, more prospective cohort studies are needed to clarify the role of air pollutants in T1DM occurrence.
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spelling pubmed-98435922023-01-18 The Association between Exposure to Air Pollution and Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis Mozafarian, Nafiseh Hashemipour, Mahin Yazdi, Maryam Hani Tabaei Zavareh, Mohsen Hovsepian, Silva Heidarpour, Maryam Taheri, Ensiyeh Adv Biomed Res Meta Analysis BACKGROUND: This systematic review and meta-analysis aimed to overview the observational studies on the association of exposure to air pollution and type 1 diabetes mellitus (T1DM). MATERIALS AND METHODS: Based on PRISMA guidelines, we systematically reviewed the databases of PubMed, Scopus, Embase, and Web of Science databases to determine the association of air pollution exposure and T1DM. Quality assessment of the papers was evaluated using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist for observational studies. The odds ratios (OR) and their 95% confidence intervals (CI) were calculated to assess the strength of the associations between air pollutants (gases and particulate matter air pollutants including PM10, PM2.5, NO2, volatile organic compound, SO4, SO2, O3) and T1DM. RESULTS: Out of 385 initially identified papers, 6 studies were used for this meta-analysis. Fixed effects meta-analysis showed a significant association between per 10 μg/m(3) increase in O3 and PM2.5 exposures with the increased risk of T1DM (3 studies, OR = 1.51, 95% CI: 1.26, 1.80, I(2) = 83.5% for O3 and two studies, OR = 1.03, 95% CI: 1.01, 1.05, I(2) = 76.3% for PM2.5). There was no evidence of association between increased risk of T1DM and exposure to PM10 (OR = 1.02, 95% CI: 0.99–1.06, I(2) = 59.4%), SO4 (OR = 1.16, 95% CI: 0.91–1.49, I(2) = 93.8%), SO2 (OR = 0.94, 95% CI: 0.83–1.06, I(2) = 85.0%), and NO2 (OR = 0.995,95% CI: 1.05–1.04, I(2) = 24.7%). CONCLUSION: Recent publications indicated that exposure to ozone and PM2.5 may be a risk factor for T1DM. However, due to limited available studies, more prospective cohort studies are needed to clarify the role of air pollutants in T1DM occurrence. Wolters Kluwer - Medknow 2022-11-28 /pmc/articles/PMC9843592/ /pubmed/36660754 http://dx.doi.org/10.4103/abr.abr_80_21 Text en Copyright: © 2022 Advanced Biomedical Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Meta Analysis
Mozafarian, Nafiseh
Hashemipour, Mahin
Yazdi, Maryam
Hani Tabaei Zavareh, Mohsen
Hovsepian, Silva
Heidarpour, Maryam
Taheri, Ensiyeh
The Association between Exposure to Air Pollution and Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis
title The Association between Exposure to Air Pollution and Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis
title_full The Association between Exposure to Air Pollution and Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis
title_fullStr The Association between Exposure to Air Pollution and Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis
title_full_unstemmed The Association between Exposure to Air Pollution and Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis
title_short The Association between Exposure to Air Pollution and Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis
title_sort association between exposure to air pollution and type 1 diabetes mellitus: a systematic review and meta-analysis
topic Meta Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843592/
https://www.ncbi.nlm.nih.gov/pubmed/36660754
http://dx.doi.org/10.4103/abr.abr_80_21
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