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Could paraprobiotics be a safer alternative to probiotics for managing cancer chemotherapy-induced gastrointestinal toxicities?
Clinical oncology has shown outstanding progress improving patient survival due to the incorporation of new drugs. However, treatment success may be reduced by the emergency of dose-limiting side effects, such as intestinal mucositis and diarrhea. Mucositis and diarrhea management is symptomatic, an...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Associação Brasileira de Divulgação Científica
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843735/ https://www.ncbi.nlm.nih.gov/pubmed/36651453 http://dx.doi.org/10.1590/1414-431X2022e12522 |
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author | Nobre, L.M.S. Fernandes, C. Florêncio, K.G.D. Alencar, N.M.N. Wong, D.V.T. Lima-Júnior, R.C.P. |
author_facet | Nobre, L.M.S. Fernandes, C. Florêncio, K.G.D. Alencar, N.M.N. Wong, D.V.T. Lima-Júnior, R.C.P. |
author_sort | Nobre, L.M.S. |
collection | PubMed |
description | Clinical oncology has shown outstanding progress improving patient survival due to the incorporation of new drugs. However, treatment success may be reduced by the emergency of dose-limiting side effects, such as intestinal mucositis and diarrhea. Mucositis and diarrhea management is symptomatic, and there is no preventive therapy. Bacterial and fungal-based compounds have been suggested as an alternative for preventing the development of diarrhea in cancer patients. Using probiotics is safe and effective in immunocompetent individuals, but concerns remain during immunosuppressive conditions. Paraprobiotics, formulations composed of non-viable microorganisms, have been proposed to overcome such limitation. The present literature review discusses current evidence regarding the possible use of paraprobiotics as an alternative to probiotics to prevent gastrointestinal toxicity of cancer chemotherapy. |
format | Online Article Text |
id | pubmed-9843735 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Associação Brasileira de Divulgação Científica |
record_format | MEDLINE/PubMed |
spelling | pubmed-98437352023-01-18 Could paraprobiotics be a safer alternative to probiotics for managing cancer chemotherapy-induced gastrointestinal toxicities? Nobre, L.M.S. Fernandes, C. Florêncio, K.G.D. Alencar, N.M.N. Wong, D.V.T. Lima-Júnior, R.C.P. Braz J Med Biol Res Review Clinical oncology has shown outstanding progress improving patient survival due to the incorporation of new drugs. However, treatment success may be reduced by the emergency of dose-limiting side effects, such as intestinal mucositis and diarrhea. Mucositis and diarrhea management is symptomatic, and there is no preventive therapy. Bacterial and fungal-based compounds have been suggested as an alternative for preventing the development of diarrhea in cancer patients. Using probiotics is safe and effective in immunocompetent individuals, but concerns remain during immunosuppressive conditions. Paraprobiotics, formulations composed of non-viable microorganisms, have been proposed to overcome such limitation. The present literature review discusses current evidence regarding the possible use of paraprobiotics as an alternative to probiotics to prevent gastrointestinal toxicity of cancer chemotherapy. Associação Brasileira de Divulgação Científica 2023-01-16 /pmc/articles/PMC9843735/ /pubmed/36651453 http://dx.doi.org/10.1590/1414-431X2022e12522 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Nobre, L.M.S. Fernandes, C. Florêncio, K.G.D. Alencar, N.M.N. Wong, D.V.T. Lima-Júnior, R.C.P. Could paraprobiotics be a safer alternative to probiotics for managing cancer chemotherapy-induced gastrointestinal toxicities? |
title | Could paraprobiotics be a safer alternative to probiotics for managing cancer chemotherapy-induced gastrointestinal toxicities? |
title_full | Could paraprobiotics be a safer alternative to probiotics for managing cancer chemotherapy-induced gastrointestinal toxicities? |
title_fullStr | Could paraprobiotics be a safer alternative to probiotics for managing cancer chemotherapy-induced gastrointestinal toxicities? |
title_full_unstemmed | Could paraprobiotics be a safer alternative to probiotics for managing cancer chemotherapy-induced gastrointestinal toxicities? |
title_short | Could paraprobiotics be a safer alternative to probiotics for managing cancer chemotherapy-induced gastrointestinal toxicities? |
title_sort | could paraprobiotics be a safer alternative to probiotics for managing cancer chemotherapy-induced gastrointestinal toxicities? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843735/ https://www.ncbi.nlm.nih.gov/pubmed/36651453 http://dx.doi.org/10.1590/1414-431X2022e12522 |
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