Association of mitochondrial homeostasis and dynamic balance with malignant biological behaviors of gastrointestinal cancer

Mitochondria determine the physiological status of most eukaryotes. Mitochondrial dynamics plays an important role in maintaining mitochondrial homeostasis, and the disorder in mitochondrial dynamics could affect cellular energy metabolism leading to tumorigenesis. In recent years, disrupted mitocho...

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Autores principales: Liu, Ao-ran, Lv, Zhi, Yan, Zi-wei, Wu, Xiao-yang, Yan, Li-rong, Sun, Li-ping, Yuan, Yuan, Xu, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843870/
https://www.ncbi.nlm.nih.gov/pubmed/36647167
http://dx.doi.org/10.1186/s12967-023-03878-1
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author Liu, Ao-ran
Lv, Zhi
Yan, Zi-wei
Wu, Xiao-yang
Yan, Li-rong
Sun, Li-ping
Yuan, Yuan
Xu, Qian
author_facet Liu, Ao-ran
Lv, Zhi
Yan, Zi-wei
Wu, Xiao-yang
Yan, Li-rong
Sun, Li-ping
Yuan, Yuan
Xu, Qian
author_sort Liu, Ao-ran
collection PubMed
description Mitochondria determine the physiological status of most eukaryotes. Mitochondrial dynamics plays an important role in maintaining mitochondrial homeostasis, and the disorder in mitochondrial dynamics could affect cellular energy metabolism leading to tumorigenesis. In recent years, disrupted mitochondrial dynamics has been found to influence the biological behaviors of gastrointestinal cancer with the potential to be a novel target for its individualized therapy. This review systematically introduced the role of mitochondrial dynamics in maintaining mitochondrial homeostasis, and further elaborated the effects of disrupted mitochondrial dynamics on the cellular biological behaviors of gastrointestinal cancer as well as its association with cancer progression. We aim to provide clues for elucidating the etiology and pathogenesis of gastrointestinal cancer from the perspective of mitochondrial homeostasis and disorder.
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spelling pubmed-98438702023-01-18 Association of mitochondrial homeostasis and dynamic balance with malignant biological behaviors of gastrointestinal cancer Liu, Ao-ran Lv, Zhi Yan, Zi-wei Wu, Xiao-yang Yan, Li-rong Sun, Li-ping Yuan, Yuan Xu, Qian J Transl Med Review Mitochondria determine the physiological status of most eukaryotes. Mitochondrial dynamics plays an important role in maintaining mitochondrial homeostasis, and the disorder in mitochondrial dynamics could affect cellular energy metabolism leading to tumorigenesis. In recent years, disrupted mitochondrial dynamics has been found to influence the biological behaviors of gastrointestinal cancer with the potential to be a novel target for its individualized therapy. This review systematically introduced the role of mitochondrial dynamics in maintaining mitochondrial homeostasis, and further elaborated the effects of disrupted mitochondrial dynamics on the cellular biological behaviors of gastrointestinal cancer as well as its association with cancer progression. We aim to provide clues for elucidating the etiology and pathogenesis of gastrointestinal cancer from the perspective of mitochondrial homeostasis and disorder. BioMed Central 2023-01-16 /pmc/articles/PMC9843870/ /pubmed/36647167 http://dx.doi.org/10.1186/s12967-023-03878-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Liu, Ao-ran
Lv, Zhi
Yan, Zi-wei
Wu, Xiao-yang
Yan, Li-rong
Sun, Li-ping
Yuan, Yuan
Xu, Qian
Association of mitochondrial homeostasis and dynamic balance with malignant biological behaviors of gastrointestinal cancer
title Association of mitochondrial homeostasis and dynamic balance with malignant biological behaviors of gastrointestinal cancer
title_full Association of mitochondrial homeostasis and dynamic balance with malignant biological behaviors of gastrointestinal cancer
title_fullStr Association of mitochondrial homeostasis and dynamic balance with malignant biological behaviors of gastrointestinal cancer
title_full_unstemmed Association of mitochondrial homeostasis and dynamic balance with malignant biological behaviors of gastrointestinal cancer
title_short Association of mitochondrial homeostasis and dynamic balance with malignant biological behaviors of gastrointestinal cancer
title_sort association of mitochondrial homeostasis and dynamic balance with malignant biological behaviors of gastrointestinal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843870/
https://www.ncbi.nlm.nih.gov/pubmed/36647167
http://dx.doi.org/10.1186/s12967-023-03878-1
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