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Gender-related differences on outcome following transcatheter mitral valve repair (TMVR): a systematic review and meta-analysis
BACKGROUND: The effect of gender on patients with mitral valve regurgitation (MR) undergoing transcatheter mitral valve repair (TMVR) remains to be defined. The aim of the present study is a comprehensive meta-analysis of studies that investigate differences between men and women after TMVR. METHODS...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843892/ https://www.ncbi.nlm.nih.gov/pubmed/36650548 http://dx.doi.org/10.1186/s13019-023-02123-6 |
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author | Yi, Kang Gao, Jie Wang, Wen-Xin Ma, Yu-Hu Wang, Wei He, Shao E. Xu, Xiao-Min Li, Peng-Fei You, Tao |
author_facet | Yi, Kang Gao, Jie Wang, Wen-Xin Ma, Yu-Hu Wang, Wei He, Shao E. Xu, Xiao-Min Li, Peng-Fei You, Tao |
author_sort | Yi, Kang |
collection | PubMed |
description | BACKGROUND: The effect of gender on patients with mitral valve regurgitation (MR) undergoing transcatheter mitral valve repair (TMVR) remains to be defined. The aim of the present study is a comprehensive meta-analysis of studies that investigate differences between men and women after TMVR. METHODS: A systematic literature search was carried out on eight databases to collect all relevant studies on gender-related outcomes of TMVR before March 1, 2021. The main outcomes of interest were mortality, cardiac function, MR class and other complications. RESULTS: A total of eight literatures were included, all of which were retrospective observational studies. Compared to women patients, men had lower postoperative New York Heart Association (NYHA) class (OR = 1.53, 95%CI [1.23, 1.91], P = 0.0001) and higher incidence of postoperative acute kidney injury (AKI) (OR = 1.25, 95%CI [1.16, 1.34], P < 0.05). There were no significant difference on mortality in 30 days (OR = 0.95, 95%CI [0.81, 1.11], P = 0.53) and in 2 years (OR = 0.99, 95%CI [0.75, 1.30], P = 0.93), mitral valve regurgitation (MR) class (OR = 1.30, 95%CI [0.97, 1.75], P = 0.08) and incidence of myocardial infarction (MI) (OR = 0.88, 95%CI [0.65, 1.18], P = 0.38), stroke (OR = 0.80, 95%CI [0.63, 1.02], P = 0.08) and bleeding in hospital (OR = 0.84, 95%CI [0.59, 1.19], P = 0.32). CONCLUSIONS: Our meta-analysis demonstrates that men undergoing TMVR have worse preoperative diseases (diabetes mellitus, coronary artery disease, renal failure and myocardial infarction) while they have superior postoperative NYHA class at one-year. There are no significantly difference in other indexes between men and women. |
format | Online Article Text |
id | pubmed-9843892 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-98438922023-01-18 Gender-related differences on outcome following transcatheter mitral valve repair (TMVR): a systematic review and meta-analysis Yi, Kang Gao, Jie Wang, Wen-Xin Ma, Yu-Hu Wang, Wei He, Shao E. Xu, Xiao-Min Li, Peng-Fei You, Tao J Cardiothorac Surg Review BACKGROUND: The effect of gender on patients with mitral valve regurgitation (MR) undergoing transcatheter mitral valve repair (TMVR) remains to be defined. The aim of the present study is a comprehensive meta-analysis of studies that investigate differences between men and women after TMVR. METHODS: A systematic literature search was carried out on eight databases to collect all relevant studies on gender-related outcomes of TMVR before March 1, 2021. The main outcomes of interest were mortality, cardiac function, MR class and other complications. RESULTS: A total of eight literatures were included, all of which were retrospective observational studies. Compared to women patients, men had lower postoperative New York Heart Association (NYHA) class (OR = 1.53, 95%CI [1.23, 1.91], P = 0.0001) and higher incidence of postoperative acute kidney injury (AKI) (OR = 1.25, 95%CI [1.16, 1.34], P < 0.05). There were no significant difference on mortality in 30 days (OR = 0.95, 95%CI [0.81, 1.11], P = 0.53) and in 2 years (OR = 0.99, 95%CI [0.75, 1.30], P = 0.93), mitral valve regurgitation (MR) class (OR = 1.30, 95%CI [0.97, 1.75], P = 0.08) and incidence of myocardial infarction (MI) (OR = 0.88, 95%CI [0.65, 1.18], P = 0.38), stroke (OR = 0.80, 95%CI [0.63, 1.02], P = 0.08) and bleeding in hospital (OR = 0.84, 95%CI [0.59, 1.19], P = 0.32). CONCLUSIONS: Our meta-analysis demonstrates that men undergoing TMVR have worse preoperative diseases (diabetes mellitus, coronary artery disease, renal failure and myocardial infarction) while they have superior postoperative NYHA class at one-year. There are no significantly difference in other indexes between men and women. BioMed Central 2023-01-17 /pmc/articles/PMC9843892/ /pubmed/36650548 http://dx.doi.org/10.1186/s13019-023-02123-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Yi, Kang Gao, Jie Wang, Wen-Xin Ma, Yu-Hu Wang, Wei He, Shao E. Xu, Xiao-Min Li, Peng-Fei You, Tao Gender-related differences on outcome following transcatheter mitral valve repair (TMVR): a systematic review and meta-analysis |
title | Gender-related differences on outcome following transcatheter mitral valve repair (TMVR): a systematic review and meta-analysis |
title_full | Gender-related differences on outcome following transcatheter mitral valve repair (TMVR): a systematic review and meta-analysis |
title_fullStr | Gender-related differences on outcome following transcatheter mitral valve repair (TMVR): a systematic review and meta-analysis |
title_full_unstemmed | Gender-related differences on outcome following transcatheter mitral valve repair (TMVR): a systematic review and meta-analysis |
title_short | Gender-related differences on outcome following transcatheter mitral valve repair (TMVR): a systematic review and meta-analysis |
title_sort | gender-related differences on outcome following transcatheter mitral valve repair (tmvr): a systematic review and meta-analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843892/ https://www.ncbi.nlm.nih.gov/pubmed/36650548 http://dx.doi.org/10.1186/s13019-023-02123-6 |
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