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Association of vitamin D status with disease severity and outcome in Indian patients with IgA nephropathy

BACKGROUND: Vitamin D deficiency has been examined as a risk factor for severity and progression of kidney disease due to its immunomodulatory effects. There is paucity of data about its impact in IgA nephropathy (IgAN). METHODS: In a retrospective cohort study, 25 (OH) vitamin D assay was performed...

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Autores principales: Farooqui, Naba, Subbiah, Arunkumar, Chaturvedi, Pradeep, Sati, Hem, Singh, Geetika, Bhowmik, Dipankar, Agarwal, Sanjay K., Bagchi, Soumita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843909/
https://www.ncbi.nlm.nih.gov/pubmed/36650464
http://dx.doi.org/10.1186/s12882-023-03061-0
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author Farooqui, Naba
Subbiah, Arunkumar
Chaturvedi, Pradeep
Sati, Hem
Singh, Geetika
Bhowmik, Dipankar
Agarwal, Sanjay K.
Bagchi, Soumita
author_facet Farooqui, Naba
Subbiah, Arunkumar
Chaturvedi, Pradeep
Sati, Hem
Singh, Geetika
Bhowmik, Dipankar
Agarwal, Sanjay K.
Bagchi, Soumita
author_sort Farooqui, Naba
collection PubMed
description BACKGROUND: Vitamin D deficiency has been examined as a risk factor for severity and progression of kidney disease due to its immunomodulatory effects. There is paucity of data about its impact in IgA nephropathy (IgAN). METHODS: In a retrospective cohort study, 25 (OH) vitamin D assay was performed in bio-banked baseline serum samples collected during kidney biopsy of 105 adult patients with primary IgAN diagnosed between 2015 and 2019. A level of < 10 ng/mL was defined as Vitamin D deficiency. RESULTS: Mean age of patients was 34 ± 10.6 years, 69.5% were males. Mean baseline 25(OH) Vitamin D levels was 15.9 ± 11.9 ng/mL and 41(39%) patients had vitamin D deficiency. Serum albumin level was lower in vitamin D deficient patients compared to those who had higher vitamin D levels (3.7 ± 0.9 vs 4.1 ± 0.7 g/dl, p = 0.018)but there was no significant difference in baseline proteinuria and eGFR. Crescentic lesions were more frequent in vitamin D deficient group (19.5% vs 6.3%, p = 0.022). At median follow up of 21.5 months (6 – 56 months), there was no difference in remission (68.3% vs 65.6%, p = 0.777) and disease progression (12.5% vs 9.4%, p = 0.614) in those with and without Vitamin D deficiency respectively. On multivariate cox proportional hazard analysis, vitamin D deficiency was not a significant risk factor for renal survival (HR-1.79, 95% confidence interval:0.50–6.34, p = 0.368). CONCLUSION: There was no association between vitamin D deficiency and disease profile as well as renal outcome in Indian patients with IgAN.
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spelling pubmed-98439092023-01-18 Association of vitamin D status with disease severity and outcome in Indian patients with IgA nephropathy Farooqui, Naba Subbiah, Arunkumar Chaturvedi, Pradeep Sati, Hem Singh, Geetika Bhowmik, Dipankar Agarwal, Sanjay K. Bagchi, Soumita BMC Nephrol Research BACKGROUND: Vitamin D deficiency has been examined as a risk factor for severity and progression of kidney disease due to its immunomodulatory effects. There is paucity of data about its impact in IgA nephropathy (IgAN). METHODS: In a retrospective cohort study, 25 (OH) vitamin D assay was performed in bio-banked baseline serum samples collected during kidney biopsy of 105 adult patients with primary IgAN diagnosed between 2015 and 2019. A level of < 10 ng/mL was defined as Vitamin D deficiency. RESULTS: Mean age of patients was 34 ± 10.6 years, 69.5% were males. Mean baseline 25(OH) Vitamin D levels was 15.9 ± 11.9 ng/mL and 41(39%) patients had vitamin D deficiency. Serum albumin level was lower in vitamin D deficient patients compared to those who had higher vitamin D levels (3.7 ± 0.9 vs 4.1 ± 0.7 g/dl, p = 0.018)but there was no significant difference in baseline proteinuria and eGFR. Crescentic lesions were more frequent in vitamin D deficient group (19.5% vs 6.3%, p = 0.022). At median follow up of 21.5 months (6 – 56 months), there was no difference in remission (68.3% vs 65.6%, p = 0.777) and disease progression (12.5% vs 9.4%, p = 0.614) in those with and without Vitamin D deficiency respectively. On multivariate cox proportional hazard analysis, vitamin D deficiency was not a significant risk factor for renal survival (HR-1.79, 95% confidence interval:0.50–6.34, p = 0.368). CONCLUSION: There was no association between vitamin D deficiency and disease profile as well as renal outcome in Indian patients with IgAN. BioMed Central 2023-01-17 /pmc/articles/PMC9843909/ /pubmed/36650464 http://dx.doi.org/10.1186/s12882-023-03061-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Farooqui, Naba
Subbiah, Arunkumar
Chaturvedi, Pradeep
Sati, Hem
Singh, Geetika
Bhowmik, Dipankar
Agarwal, Sanjay K.
Bagchi, Soumita
Association of vitamin D status with disease severity and outcome in Indian patients with IgA nephropathy
title Association of vitamin D status with disease severity and outcome in Indian patients with IgA nephropathy
title_full Association of vitamin D status with disease severity and outcome in Indian patients with IgA nephropathy
title_fullStr Association of vitamin D status with disease severity and outcome in Indian patients with IgA nephropathy
title_full_unstemmed Association of vitamin D status with disease severity and outcome in Indian patients with IgA nephropathy
title_short Association of vitamin D status with disease severity and outcome in Indian patients with IgA nephropathy
title_sort association of vitamin d status with disease severity and outcome in indian patients with iga nephropathy
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843909/
https://www.ncbi.nlm.nih.gov/pubmed/36650464
http://dx.doi.org/10.1186/s12882-023-03061-0
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