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Experimental analysis of bladder cancer-associated mutations in EP300 identifies EP300-R1627W as a driver mutation

BACKGROUND: Bladder cancer (BCa) is the most common malignant tumor of the urinary system, with transitional cell carcinoma (TCC) being the predominant type. EP300 encodes a lysine acetyltransferase that regulates a large subset of genes by acetylating histones and non-histone proteins. We previousl...

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Detalles Bibliográficos
Autores principales:	Luo, Mayao, Zhang, Yifan, Xu, Zhuofan, Lv, Shidong, Wei, Qiang, Dang, Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843983/ https://www.ncbi.nlm.nih.gov/pubmed/36647005 http://dx.doi.org/10.1186/s10020-023-00608-7

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