Unmasking the biological function and regulatory mechanism of NOC2L: a novel inhibitor of histone acetyltransferase

NOC2 like nucleolar associated transcriptional repressor (NOC2L) was recently identified as a novel inhibitor of histone acetyltransferase (INHAT). NOC2L is found to have two INHAT function domains and regulates histone acetylation in a histone deacetylases (HDAC) independent manner, which is distin...

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Detalles Bibliográficos
Autores principales: Lu, Siyi, Chen, Zhaoyu, Liu, Zhenzhen, Liu, Zhentao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844006/
https://www.ncbi.nlm.nih.gov/pubmed/36650543
http://dx.doi.org/10.1186/s12967-023-03877-2
Descripción
Sumario:NOC2 like nucleolar associated transcriptional repressor (NOC2L) was recently identified as a novel inhibitor of histone acetyltransferase (INHAT). NOC2L is found to have two INHAT function domains and regulates histone acetylation in a histone deacetylases (HDAC) independent manner, which is distinct from other INHATs. In this review, we summarize the biological function of NOC2L in histone acetylation regulation, P53-mediated transcription, ribosome RNA processing, certain development events and carcinogenesis. We propose that NOC2L may be explored as a potential biomarker and a therapeutic target in clinical practice. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12967-023-03877-2.

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