Unmasking the biological function and regulatory mechanism of NOC2L: a novel inhibitor of histone acetyltransferase

NOC2 like nucleolar associated transcriptional repressor (NOC2L) was recently identified as a novel inhibitor of histone acetyltransferase (INHAT). NOC2L is found to have two INHAT function domains and regulates histone acetylation in a histone deacetylases (HDAC) independent manner, which is distin...

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Detalles Bibliográficos
Autores principales: Lu, Siyi, Chen, Zhaoyu, Liu, Zhenzhen, Liu, Zhentao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844006/
https://www.ncbi.nlm.nih.gov/pubmed/36650543
http://dx.doi.org/10.1186/s12967-023-03877-2
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author Lu, Siyi
Chen, Zhaoyu
Liu, Zhenzhen
Liu, Zhentao
author_facet Lu, Siyi
Chen, Zhaoyu
Liu, Zhenzhen
Liu, Zhentao
author_sort Lu, Siyi
collection PubMed
description NOC2 like nucleolar associated transcriptional repressor (NOC2L) was recently identified as a novel inhibitor of histone acetyltransferase (INHAT). NOC2L is found to have two INHAT function domains and regulates histone acetylation in a histone deacetylases (HDAC) independent manner, which is distinct from other INHATs. In this review, we summarize the biological function of NOC2L in histone acetylation regulation, P53-mediated transcription, ribosome RNA processing, certain development events and carcinogenesis. We propose that NOC2L may be explored as a potential biomarker and a therapeutic target in clinical practice. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12967-023-03877-2.
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spelling pubmed-98440062023-01-18 Unmasking the biological function and regulatory mechanism of NOC2L: a novel inhibitor of histone acetyltransferase Lu, Siyi Chen, Zhaoyu Liu, Zhenzhen Liu, Zhentao J Transl Med Review NOC2 like nucleolar associated transcriptional repressor (NOC2L) was recently identified as a novel inhibitor of histone acetyltransferase (INHAT). NOC2L is found to have two INHAT function domains and regulates histone acetylation in a histone deacetylases (HDAC) independent manner, which is distinct from other INHATs. In this review, we summarize the biological function of NOC2L in histone acetylation regulation, P53-mediated transcription, ribosome RNA processing, certain development events and carcinogenesis. We propose that NOC2L may be explored as a potential biomarker and a therapeutic target in clinical practice. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12967-023-03877-2. BioMed Central 2023-01-17 /pmc/articles/PMC9844006/ /pubmed/36650543 http://dx.doi.org/10.1186/s12967-023-03877-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Lu, Siyi
Chen, Zhaoyu
Liu, Zhenzhen
Liu, Zhentao
Unmasking the biological function and regulatory mechanism of NOC2L: a novel inhibitor of histone acetyltransferase
title Unmasking the biological function and regulatory mechanism of NOC2L: a novel inhibitor of histone acetyltransferase
title_full Unmasking the biological function and regulatory mechanism of NOC2L: a novel inhibitor of histone acetyltransferase
title_fullStr Unmasking the biological function and regulatory mechanism of NOC2L: a novel inhibitor of histone acetyltransferase
title_full_unstemmed Unmasking the biological function and regulatory mechanism of NOC2L: a novel inhibitor of histone acetyltransferase
title_short Unmasking the biological function and regulatory mechanism of NOC2L: a novel inhibitor of histone acetyltransferase
title_sort unmasking the biological function and regulatory mechanism of noc2l: a novel inhibitor of histone acetyltransferase
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844006/
https://www.ncbi.nlm.nih.gov/pubmed/36650543
http://dx.doi.org/10.1186/s12967-023-03877-2
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